90348-64-4Relevant academic research and scientific papers
Preparation process of 7-chlorine-4-hydroxyl dihydroindene
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Paragraph 0020; 0021, (2018/09/11)
The invention discloses a preparation process of 7-chlorine-4-hydroxyl dihydroindene in the field of the organic chemical industry. The preparation process comprises the following steps: (1) carryingout phenol hydroxyl esterification reaction via p-chloro
Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors
Tsukada, Tomoharu,Takahashi, Mizuki,Takemoto, Toshiyasu,Kanno, Osamu,Yamane, Takahiro,Kawamura, Sayako,Nishi, Takahide
scheme or table, p. 1004 - 1007 (2010/06/16)
With the goal of improving metabolic stability and further enhancing FBPase inhibitory activity, a series of tricyclic 8H-indeno[1,2-d][1,3]thiazoles was designed and synthesized with the aid of structure-based drug design. Extensive SAR studies led to th
Bicyclic amino-substituted compounds
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, (2008/06/13)
A compound of formula (I), wherein X is O, CH 2, S, SO or SO 2 ; R is F or Cl; R 1 is H, C 1 -C 6 alkyl or C 2 -C 6 alkenyl; R 2 is H, C 1 -C 6 alkyl or C 2 -C 6 alkenyl; R 3 is H, C 1 -C 6, alkyl, a pharmaceutically acceptable salt thereof, an enantiomer thereof, and a pharmaceutically acceptable salt of said enantiomer for use in therapy. A pharmaceutical preparation containing as active ingredient any one of said compounds. A process for the preparation of a compound of formula (I).
