903515-97-9

Basic information

• Product Name: Bicyclo[2.2.1]heptan-2-one, 3-[(4-fluorophenyl)methylene]-1,7,7-trimethyl-, (1S,3E,4R)-
• CAS NO: 903515-97-9
• Molecular Formula: C17H19FO
• Molecular Weight: 258.336
• Mol File: 903515-97-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Bicyclo[2.2.1]heptan-2-one, 3-[(4-fluorophenyl)methylene]-1,7,7-trimethyl-, (1S,3E,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[2.2.1]heptan-2-one, 3-[(4-fluorophenyl)methylene]-1,7,7-trimethyl-, (1S,3E,4R)-(903515-97-9)
• EPA Substance Registry System: Bicyclo[2.2.1]heptan-2-one, 3-[(4-fluorophenyl)methylene]-1,7,7-trimethyl-, (1S,3E,4R)-(903515-97-9)

Safety Data

• Hazardous Substances Data: 903515-97-9(Hazardous Substances Data)

Upstream product

• 902750-70-3 (1S,3E,4R)-3-[(dimethylamino)methylidene]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 
• 352-13-6 4-flourophenylmagnesium bromide 
• 464-48-2 (1S)-camphor 

Relevant articles and documents

Stereoselective additions to the exocyclic C{double bond, long}C bond of some α-alkylidene-(+)-camphor derivatives

Stereoselective additions to the exocyclic C{double bond, long}C double bond of some (1R,3E,4S)-3-alkylidene-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ones and (1R,4E,5S)-4-alkylidene-1,8,8-trimethyl-2-oxabicyclo[3.2.1]octan-3-ones were studied. All additions took place predominantly from the less hindered endo-face of the methylidene compounds to give the corresponding exo-adducts as the major isomers. Thus, catalytic hydrogenations afforded the α-alkylated (1R,3R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ones and (1R,4R,5R)-1,8,8-trimethyl-2-oxabicyclo[3.2.1]octan-3-ones in 28-100% de. Similarly, 1,3-dipolar cycloadditions of 2,4,6-trisubstituted benzonitrile oxides gave the corresponding spiro cycloadducts in 66-100% de. The structures were determined by 2D NMR techniques, NOESY spectroscopy and X-ray diffraction.