903520-36-5

Upstream product

• 34126-16-4 4-bromo-3,5-dihydroxy-benzoic acid methyl ester 
• 107-30-2 chloromethyl methyl ether 
• 16534-12-6 3,5-dihydroxy-4-bromobenzoic acid 

Downstream Products

• 1054623-84-5 (3R,4R)-4-[4-(2-Benzyloxy-6-benzyloxycarbonyl-benzoyl)-3,5-bis-methoxymethoxy-benzoyloxy]-3-[4-(tert-butyl-dimethyl-silanyloxy)-benzoylamino]-azepane-1-carboxylic acid tert-butyl ester 
• 444119-75-9 [4-bromo-3,5-bis(methoxymethoxy)phenyl]methoxy tert-butyldimethylsilane 
• 903520-37-6 (3,5-bis(methoxymethoxy)-4-bromophenyl) methanol 

Relevant academic research and scientific papers

Total Synthesis of Gramistilbenoids A, B, and C

Stilbenes are biologically active metabolites of plants that have the potential to attenuate a broad range of human diseases. Gramistilbenoids are a class of natural products with a stilbene skeleton, isolated from the bamboo orchid (Arundina graminifolia), and with significant cytotoxicity against cancer cell lines (NB4, A549, SHSY5Y, PC3, and MCF7). These are the first identified naturally occurring diphenylethylenes to possess a hydroxyethyl unit. However, some of these compounds are not abundant in nature, and thus, their synthesis is advantageous. This paper reports the first synthesis of gramistilbenoids A (1), B (2), and C (3), with overall yields of 10, 2, and 8% respectively. These natural products were synthesized using key reactions, such as Horner-Wadsworth-Emmons olefination, Stille coupling, and hydroboration-oxidation.

First total synthesis of mappain with a prenylated and geranylated stilbene

The first total synthesis of naturally occurring mappain has been achieved by a convergent sequence. The key strategy involved in the synthesis of mappain was a (E)-stilbene formation by Horner -Wadsworth -Emmons reaction of the corresponding prenylated b

Effect of substituents on the molecular shapes of π-basic macrotricyclic receptors

Molecular recognition between receptor and substrate is optimized when these compounds show complementary shapes, sizes, and interacting moieties. A family of C3v-symmetric macrotricycles 1-4 is presented that incorporate resorcinol- and mesity

Total synthesis of (+)-machaeriol D with a key regio- and stereoselective SN2′ reaction

(Chemical Equation Presented) A general strategy for the synthesis of hexahydrodibenzopyrans (HHDBPs) is illustrated in the enantioselective total synthesis of (+)-machaeriol D. In the key step, an SN2′ reaction of an aryl cyanocuprate with a s

Total synthesis of enantiomerically pure (-)-Balanol

The total synthesis of enantiomerically pure (-)-Balanol (1), using tri-O-acetyl-D-glucal as a chiral template for the central azepane fragment is described.