903528-01-8

Upstream product

• 903528-00-7 methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4931-66-2 methyl 5-oxopyrrolidine-2-carboxylate 
• 3587-60-8 Benzyloxymethyl chloride 

Downstream Products

• 903528-02-9 1-tert-butyl 2-methyl 2-[(benzyloxy)methyl]-5-oxo-1H-pyrrole-1,2-(2H,5H)-dicarboxylate 

Relevant academic research and scientific papers

Nitrone [2+3]-cycloadditions in stereocontrolled synthesis of a potent proteasome inhibitor: (-)-Omuralide

(Chemical Equation Presented) A new stereocontrolled synthetic route to omuralide has been developed from methyl pyroglutamate. This route involves regio- and stereoselective N-methylnitrone 1,3-dipolar cycloadditions to appropriate pyrrolinones, β-eliminations, and highly selective hydrogenations as the main steps.

Studies toward the synthesis of salinosporamide A, a potent proteasome inhibitor

An α-methylenepyrrolidinone bearing all the functionalities and relative configurations of an advanced intermediate in the synthesis of salinosporamide A and analogues has been synthesized from methyl pyroglutamate through regio- and stereoselective N-methylnitrone cycloaddition.