903528-00-7

Basic information

• Product Name: methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate
• Synonyms: methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate
• CAS NO: 903528-00-7
• Molecular Weight: 263.293
• Mol File: 903528-00-7.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate(903528-00-7)
• EPA Substance Registry System: methyl 2-((benzyloxy)methyl)-5-oxopyrrolidine-2-carboxylate(903528-00-7)

Safety Data

• Hazardous Substances Data: 903528-00-7(Hazardous Substances Data)

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 4931-66-2 methyl 5-oxopyrrolidine-2-carboxylate 
• 64700-65-8 methyl (2R)-pyroglutamate 
• 872832-89-8 methyl (+/-)-2-hydroxymethyl-5-oxopyrrolidine-2-carboxylate 
• 882980-43-0 2-benzyloxy-1-methylpyridinium triflate 

Downstream Products

• 903528-02-9 1-tert-butyl 2-methyl 2-[(benzyloxy)methyl]-5-oxo-1H-pyrrole-1,2-(2H,5H)-dicarboxylate 
• 903528-01-8 1-tert-butyl 2-methyl 2-[(benzyloxy)methyl]-5-oxo-pyrrolidine-1,2-dicarboxylate 

Relevant articles and documents

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The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).

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(Chemical Equation Presented) A new stereocontrolled synthetic route to omuralide has been developed from methyl pyroglutamate. This route involves regio- and stereoselective N-methylnitrone 1,3-dipolar cycloadditions to appropriate pyrrolinones, β-eliminations, and highly selective hydrogenations as the main steps.

Studies toward the synthesis of salinosporamide A, a potent proteasome inhibitor

An α-methylenepyrrolidinone bearing all the functionalities and relative configurations of an advanced intermediate in the synthesis of salinosporamide A and analogues has been synthesized from methyl pyroglutamate through regio- and stereoselective N-methylnitrone cycloaddition.