903563-88-2

Upstream product

• 108164-67-6 3-(2-chlorophenyl)-3-hydroxy-2-methylenepropionitrile 
• 423157-61-3 1-(2-chlorophenyl)-2-cyanoallyl acetate 

Downstream Products

• 903563-96-2 1-[3-(2-chloro-phenyl)-2-cyano-allyl]-3-(3,4-dichloro-phenyl)-urea 
• 903563-98-4 1-[3-(2-chloro-phenyl)-2-cyano-allyl]-3-phenyl-thiourea 
• 903563-94-0 1-(4-chloro-phenyl)-3-[3-(2-chloro-phenyl)-2-cyano-allyl]-urea 
• 903563-97-3 1-(3-chloro-4-methyl-phenyl)-3-[3-(2-chloro-phenyl)-2-cyano-allyl]-urea 
• 903563-95-1 1-[3-(2-chloro-phenyl)-2-cyano-allyl]-3-(2,4-dichloro-phenyl)-urea 

Relevant academic research and scientific papers

Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives

The synthesis of several 1-(2-cyano-3-aryl-allyl)-3-aryl-urea(thiourea) constructed from the reaction between allylamines generated from Baylis-Hillman acetates and substituted isocyanates and isothiocyanates has been described. Further, their cyclization in the presence of a base led to the formation of 5-arylmethyl-4-imino-3-aryl-3,4-dihydro-1H-pyrimidin-2-ones. All compounds were tested for their antibacterial activity. Few of the compounds showed superior activity or were equipotent to the standard antibacterial agents.

Alternate, easy and practical synthesis of allylamines from acetyl derivatives of Baylis-Hillman adducts using methanolic ammonia

A methanolic ammonia-mediated alternate, easy and practical stereoselective synthesis of allylamines from the acetyl derivatives of Baylis-Hillman adducts is described. Georg Thieme Verlag Stuttgart.