903563-96-2Relevant academic research and scientific papers
Synthesis and antibacterial evaluation of ureides of Baylis-Hillman derivatives
Nag, Somnath,Pathak, Richa,Kumar, Manish,Shukla,Batra, Sanjay
, p. 3824 - 3828 (2007/10/03)
The synthesis of several 1-(2-cyano-3-aryl-allyl)-3-aryl-urea(thiourea) constructed from the reaction between allylamines generated from Baylis-Hillman acetates and substituted isocyanates and isothiocyanates has been described. Further, their cyclization in the presence of a base led to the formation of 5-arylmethyl-4-imino-3-aryl-3,4-dihydro-1H-pyrimidin-2-ones. All compounds were tested for their antibacterial activity. Few of the compounds showed superior activity or were equipotent to the standard antibacterial agents.
