903572-34-9

Upstream product

• 934802-62-7 1-(2,4-dinitrophenyl)-3-methyluracil 
• 903572-19-0 1-(2,4-dinitro-phenyl)-1H-pyrimidine-2,4-dione 
• 70-34-8 2,4-Dinitrofluorobenzene 

Downstream Products

• 97-02-9 2,4-Dinitroanilin 
• 934802-64-9 3-methyl-5-nitro-1-phenyluracil 

Relevant academic research and scientific papers

New approach for the synthesis of 1-aryl- and 1-heteroaryl-5-nitrouracil derivatives

1-(2,4-Dinitrophenyl)-5-nitrouracil and its 3-methyl derivatives were synthesized and used as substrates in reaction with aromatic amines and amino pyridines. In the reaction of aniline with 1-(2,4-dinitrophenyl)-5-nitrouracil, only the acyclic adduct was isolated. When 1-(2,4-dinitrophenyl)-3-methyl-5-nitrouracil was treated with aniline and other aromatic amines or amino pyridines, the desired 1-aryl-5-nitrouracil derivatives were obtained in satisfactory yield. The influence of the free H-3 proton present in the uracil ring on the course of the reaction is discussed.

A convenient method for N-1 arylation of uracil derivatives

1-(4-Nitrophenyl)- and 1-(2,4-dinitrophenyl)uracil derivatives have been obtained by direct arylation of uracil and its 5-substituted derivatives using 1-fluoro-4-nitrobenzene or 1-fluoro-2,4-dinitrobenzene in the presence of a base. The application of the newly obtained uracil derivatives in further synthesis is also presented.