903594-17-2

Upstream product

• 903594-16-1 1,9-dibenzyl-6,9-dihydro-6-oxo-8-bromopurine 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 56046-34-5 9-benzyl-8-bromo-9H-purin-6-amine 
• 100-39-0 benzyl bromide 
• 4261-14-7 9-benzyl-9H-purin-6-ylamine 

Downstream Products

• 958867-89-5 methyl 4-(1,9-dibenzyl-6,9-dihydro-6-oxo-1H-purin-8-yl)-2-hydroxy-4-oxobut-2-enoate 

Relevant academic research and scientific papers

A novel strategy to assemble the β-diketo acid pharmacophore of HIV integrase inhibitors on purine nucleobase scaffolds

(Chemical Equation Presented) Claisen condensation, the key step in constructing the pharmacophore of aryl β-diketo acids (DKA) as integrase inhibitors, fails in certain cases of highly electron-deficient heterocycles such as purines. A general synthetic

DIKETO ACIDS WITH NUCLEOBASE SCAFFOLDS: ANTI-HIV REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE IN COMBINATION THERAPY

A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HFV and in the treatmen

Biologically-validated HIV integrase inhibitors with nucleobase scaffolds: Structure, synthesis, chemical biology, molecular modeling, and antiviral activity

Integrase, an enzyme of the pol gene of HIV, is a significant viral target for the discovery of anti-HIV agents. In this presentation, we report on the continuation of our work on the discovery of diketo acids, constructed on nucleobase scaffolds, that ar

Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase

A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatmen

Diketo acids on nucleobase scaffolds as inhibitors of Flaviviridae

A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HCV replication through inhibition of HCV NS5B RNA polymerase, is described. These compounds are useful in the prevention or treatment of infection by HCV and in th