90362-50-8Relevant academic research and scientific papers
5′-O-Masked 2′-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents
Ikejiri, Masahiro,Ohshima, Takayuki,Kato, Keizo,Toyama, Masaaki,Murata, Takayuki,Shimotohno, Kunitada,Maruyama, Tokumi
, p. 6882 - 6892 (2008/04/12)
On the basis of our previous study on antiviral agents against the severe acute respiratory syndrome (SARS) coronavirus, a series of nucleoside analogues whose 5′-hydroxyl groups are masked by various protective groups such as carboxylate, sulfonate, and
ADA-Bypass by lipophilic cycloSal-ddAMP pro-nucleotides. A second example of the efficiency of the cycloSal-concept
Meier, Chris,Knispel, Tina,De Clercq,Balzarini, Jan
, p. 1577 - 1582 (2007/10/03)
The synthesis of lipophilic pro-nucleotides of ddAMP 2 based on cycloSal-ddAMP 3a-c is described. Phosphotriesters 3 released ddAMP 2 selectively by a controlled, chemically induced tandem reaction. CycloSal-phosphotriesters 3 exhibited antiviral activity against HIV-1/HIV-2 in CEM cells that where by a factor up to hundred higher as compared to ddA 1.
