90381-02-5

Upstream product

• 890933-16-1 2-chloro-4-fluorobenzal chloride 
• 890933-15-0 2-chloro-5-fluorobenzal chloride 
• 88578-92-1 2-chloro-4-fluoro-benzotrichloride 
• 890933-17-2 2-chloro-5-fluorobenzotrichloride 
• 890933-14-9 3,4-bis(dichloromethyl)fluorobenzene 
• 890933-13-8 2-trichloromethyl-4-fluorobenzal chloride 
• 852462-69-2 2-trichloromethyl-5-fluorobenzal chloride 

Relevant academic research and scientific papers

FLUORINE-CONTAINING BENZAL CHLORIDE AND METHOD FOR PRODUCING THE SAME

PROBLEM TO BE SOLVED: To provide 2-trifluoromethyl-5-fluorobenzal chloride and 2-trifluoromethyl-4-fluorobenzal chloride useful as a medicinal or an agrochemical intermediate, etc., and a method for producing them. SOLUTION: The 2-trifluoromethyl-5-fluorobenzal chloride is obtained by chlorinating 3,4-dimethylfluorobenzene with chlorine (Cl2) to obtain an isomer mixture (chlorination reaction mixture) of 2-trichloromethyl-5-fluorobenzal chloride and 2-trichloromethyl-4-fluorobenzal chloride, bringing the obtained isomer mixture in contact with hydrogen fluoride (HF) to obtain the fluorination reaction mixture, distilling the fluorination reaction mixture to be able to isolate 2-trifluoromethyl-5-fluorobenzal chloride. On the one hand, by reacting the distillation residue with HF under a condition for accelerating the reaction or for a longer period, 2-trifluoromethyl-4-fluorobenzal chloride is obtained.