903876-75-5

Upstream product

• 280119-78-0 1-[4-methoxyphenyl]-3-cyano-4-azido-5-[4-bromophenylaminocarbonyl]pyrazole 
• 67-56-1 methanol 
• 280119-44-0 Methyl (1-[4-Methoxyphenyl]-3-cyano-4-amino)pyrazole-5-carboxylate 
• 280119-48-4 (1-[4-Methoxyphenyl]-3-cyano-4-azido)pyrazole-5-carboxylic acid 
• 280119-45-1 Methyl (1-[4-Methoxyphenyl]-3-cyano-4-azido)pyrazole-5-carboxylate 
• 104-94-9 4-methoxy-aniline 
• 1209-14-9 2-[2-(4-methoxyphenyl)hydrazono]malononitrile 

Downstream Products

• 280119-59-7 1-[4-methoxyphenyl]-3-(methoxycarbonyl)-6-[4-bromophenyl]-1,6-dihydropyrazolo-[4,3-d]-pyrimidin-7-one 
• 903876-79-9 6-(2'-tert-butylsulfamoyl-biphenyl-4-yl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid 
• 903876-77-7 6-(2'-tert-butylsulfamoyl-biphenyl-4-yl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid amide 
• 280119-60-0 6-(2'-tert-butylsulfamoyl-biphenyl-4-yl)-1-(4-methoxy-phenyl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid methyl ester 
• 903876-78-8 4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide 
• 280117-16-0 4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide 

Relevant academic research and scientific papers

Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa

Previously, potent factor Xa inhibitors were described based on a pyrazole core. Modifications of the pyrazole core have provided additional novel, highly potent factor Xa inhibitors. This manuscript will describe the synthesis and biological activity of