90407-15-1

Usage

Uses

Used in Pharmaceutical Industry:
7-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of various drugs. Its unique chemical structure allows it to be a building block for the development of new compounds with potential therapeutic applications.
Used in Agrochemical Industry:
7-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID is used in the synthesis of pesticides. Its chemical properties make it a valuable component in the development of effective and targeted agrochemicals.
Used in Material Science:
7-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID has potential as a building block for the development of new materials with biomedical applications. Its unique structure and properties can be utilized to create innovative materials for various industries.
Used in Biological Research:
7-CHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID has been studied for its potential biological activities, such as anti-inflammatory and anticancer properties. Its ability to modulate various biological pathways makes it a promising candidate for further research and development in the field of medicine.

Upstream product

• 55163-91-2 ethyl thioglycolate sodium salt 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 608-27-5 2,3-dichloroaniline 

Downstream Products

• 90407-16-2 7-chlorobenzo[b]thiophene-2-carboxylic acid 

Relevant academic research and scientific papers

MODULATORS FOR NICOTINIC ACETYLCHOLINE RECEPTOR α2 AND α4 SUBUNITS

Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChR) are important therapeutic candidates as well as valuable research tools. We identified a novel type II PAM, (R)-7-bromo-N-(piperidin-3-yl)benzo[b]thiophene-2-carboxamide (B

7-Substituted Benzothiophenes and 1,2-Benzisothiazoles. Part 2. Chloro and Nitro Derivatives

The 7-chloro and 7-nitro derivatives of benzothiophene and 1,2-benzisothiazole have been prepared from readily available precursors, which for each substituent are common to both ring systems. 7-Chlorobenzothiophene has been obtained from 3-chloro-2-mercaptobenzoic acid via 7-chlorobenzothiophen-3(2H)-one, or from 2,3-dichlorobenzaldehyde, either via β-(2,3-dichlorophenyl)-α-mercaptoacrylic acid (16) or, preferably, via 7-chlorobenzothiophene-2-carboxylic acid.Hexamethylphosphoric triamide is a particularly useful solvent in which to effect the selective nucleophilic replacement of the 2-chloro substituent in 2,3-dichlorobenzaldehyde. 7-Chloro-1,2-benzisothiazole is available by treatment of 3-chloro-2-mercaptobenzaldehyde with chloramine (57percent), or by heating 2,3-dichlorobenzaldehyde with sulphur and aqueous ammonia (46percent). 7-Nitrobenzothiophene has been obtained by treatment of 2-bromo-3-nitrobenzaldehyde with mercaptoacetic acid under alkaline conditions, followed by decarboxylation of the resulting 2-carboxylic acid.Cyclisation of 2-(n- or t-butylthio)-3-nitrobenzaldoxime with polyphosphoric acid gives 7-nitro-1,2-benzisothiazole in high yield. 3-Nitro-2-t-bytylthiobenzaldehyde behaves unexpectedly with chloramine, to give what is believed to be 7-nitro-2-t-butyl-1,2-benzothiazolium chloride (24) (73percent).