90429-49-5

Upstream product

• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 613-94-5 benzoic acid hydrazide 

Downstream Products

• 185320-09-6 [Pd(NCCH₃)(C₁₉H₁₃N₃O)] 
• 1217356-32-5 Cu(2-benzoylpyridine benzhydrazone^(1-))Cl*H₂O 
• 1217356-37-0 Cu(2-benzoylpyridine benzhydrazone^(1-))N₃*H₂O 
• 1217356-39-2 Cu(2-benzoylpyridine benzhydrazone^(1-))NCS*H₂O*MeOH 
• 1217356-31-4 Cu(2-benzoylpyridine benzhydrazone^(1-))2 
• 1217356-33-6 Cu(2-benzoylpyridine benzhydrazone^(1-))Br 

Relevant academic research and scientific papers

Synthesis, spectral properties and DNA binding and nuclease activity of lanthanide (III) complexes of 2-benzoylpyridine benzhydrazone: X-ray crystal structure, Hirshfeld studies and nitrate-π interactions of cerium(III) complex

The lanthanide(III) complexes of general formula of [Ln(BPBH)2(NO3)3] (where, Ln = La, Ce, Pr, Nd and BPBH = 2-benzoylpyridine benzhydrazone) have been synthesized and characterized by elemental analysis, molar conductance

Evaluation of DNA binding, DNA cleavage, protein binding and in vitro cytotoxic activities of bivalent transition metal hydrazone complexes

Divalent Co, Ni and Cu hydrazone complexes containing [N′- (phenyl(pyridine-2-yl)methylidene) benzohydrazide] ligand were synthesised and characterised. Interactions of these complexes with DNA revealed an intercalative mode of binding between them. Further, all the hydrazone chelates showed moderate ability to cleave pUC19 DNA. Synchronous fluorescence spectra proved that the interaction of metal complexes with bovine serum albumin (BSA) resulted in a conformational change of the latter. Assay on the cytotoxicity of the above complexes against HeLa tumor cells and NIH 3T3 normal cells revealed that the complexes are toxic only against tumor cells but not to normal cells. In all the biological assays, the complex with copper ion as the metal center showed enhanced activities than the other two.

Diversities in the chelation of aroylhydrazones towards cobalt(II) salts: Synthesis, spectral characterization, crystal structure and some theoretical studies

Five cobalt complexes synthesized from two aroylhydrazones were characterized by elemental analyses, thermogravimetric analysis, molar conductivity, magnetic susceptibility measurements, IR and electronic spectra. Single crystal X-ray structure of one of the complex is also reported and it got crystallized in triclinic space group P1ˉ and the crystal structure shows a distorted octahedral geometry around the metal center. Spectral data reveal that both the aroylhydrazones are tridentate and coordinate through the azomethine nitrogen, hydrazonic oxygen, and pyridyl nitrogen. Magnetic susceptibility measurements confirm the paramagnetic nature of the Co(II) complexes and one of the complex was found to be diamagnetic in nature. Additionally, HF/6-311G(d,p)/LANL2DZ calculations were performed to predict the possible intramolecular interactions contributing to the lowering of the stabilization energy. Accordingly, π→ π* transitions were found to be responsible for the stabilization energy for the ligands and their cobalt complexes. To describe and discuss the chemical reactivity and stability of synthesized complexes, quantum chemical parameters like frontier orbital energies, hardness, softness, energy gap, electronegativity, chemical potential, electrophilicity, polarizability and dipole moment were calculated. Also, the main electronic structure principles such as maximum hardness, minimum polarizability, and minimum electrophilicity principles were considered to evaluate the stability of the complexes.

Synthesis, crystal structure and superoxide dismutase activity of two new bis(μ-acetato/μ-nitrato) bridged copper(II) complexes with N′-[phenyl(pyridin-2-yl)methylidene]benzohydrazone

Two homodinuclear copper(II) end-on bis(μ-acetato/μ-nitrato) bridged complexes with two NNO donor ligands, viz., [(L)Cu(μ-CH3COO) 2Cu(L)] (1) and [(L)Cu(μ-NO3)2Cu(L)] (2) (where L = N′-[phenyl(pyridin-2-yl)methylidene]benzohydrazone) are reported. Both complexes are structurally characterized using single crystal X-ray diffraction studies and belong to monoclinic crystal system having space group P21/n. The distance between two copper centers is 3.344(8) and 3.406(7) A? respectively for 1 and 2. On the basis of density function theory (DFT) calculations, the electronic excitations involve transitions mainly from metal-ligand bonding MOs to the β-LUMO within the dominant Cu d xy character and to β-LUMO+1. Epr spectra for polycrystalline samples exhibited the copper(II) hyperfine structures as well as zero-field splitting which are appropriate for triplet state of such a dimmers. Complexes effectively catalyze the dismutation of superoxide (O2) in alkaline nitro blue tetrazolium chloride assay and IC50 values were determined.

Synthesis, molecular docking studies, anticancer and antibacterial activities of some novel dinuclear nickel (Ii) complexes 2, 4-dihydroxy acetyl-4-hydroxybenzoic hydrazone

Substituted 2, 4-Dihydroxyacetyl-4-Hydroxybenzoic Hydrazone, which is known for their versatile biological activities, have been reported to show significant anti lung cancer activities. In the present study, a novel series of some 2, 4-Dihydroxyacetyl-4-

Organometallic ruthenium(II) complexes: Synthesis, structure and influence of substitution at azomethine carbon towards DNA/BSA binding, radical scavenging and cytotoxicity

Bivalent, ruthenium organometallics containing hydrazone ligands with the composition [RuH(CO)(PPh3)2(L1-3)] (4-6) have been synthesised from the reactions of [RuH2(CO)(PPh 3)3] and benzoic

Synthesis, crystal structure, spectroscopic and superoxide dismutase activity of copper(II) and nickel(II) complex of N'-[phenyl(pyridin-2-yl) methylidene]benzohydrazone

Two binary copper(II) and nickel(II) complexes viz., [Cu(L)(HL)]NO 3.H2O (1) and [Ni(L)(HL)]NO3.H2O (2) of hydrazone Schiff base ligand (where L/HL = N'-[phenyl(pyridin-2- yl)methylidene]benzohydrazone) have been synthesized and characterized. Both the complexes (1) and (2) and ligand (HL) are structurally characterized using single crystal X-ray diffraction technique. They crystallize in monoclinic crystal system in the space group P21/n. The observed trends in spin-Hamiltonian parameters g∥>g⊥>2.03 indicates a dx 2-y2 ground state in complex (1). In the absorption spectra in 100% DMSO, complex (2) exhibits a d-d transition at ～900 nm, which is assigned to ν1 band (3A2g→ 3T2g in octahedral parentage). Superoxide dismutase activities of both complexes reveal the dismutation of superoxide (O 2-).

Design and characterization of Cu(II) complexes from 2-benzoylpyridine benzhydrazone: Crystallographic evidence for coordination versatility

The syntheses and characterization of six copper(II) complexes of 2-benzoylpyridine benzhydrazone in the form of [Cu(BPB)2], [Cu(BPB)Cl]·H2O, [Cu(BPB)Br], [Cu2(BPB)2](ClO4)2·4H2O, [Cu(BPB)N3]·H2O, and [Cu(BPB)NCS]·H2O·CH3OH are reported. The analytical methods used for the characterization of complexes include partial elemental analyses, IR, electronic and EPR spectra, conductivity measurements, magnetic susceptibility measurements and single crystal X-ray diffraction. From the crystal structure, it is clear that the hydrazone adopts the E conformation about the azo bond to attach to the metal through the Npy-Nazo-O chelating system. In the EPR spectra of complexes in DMF at 77 K four hyperfine quartets in the parallel region could be resolved and a half field signal is observed at 1500 G for complex [Cu2(BPB)2](ClO4)2·4H2O in polycrystalline state at 298 K which gives evidence for its binuclear nature indicating a weak interaction between the two Cu(II) ions.