904324-81-8

Basic information

• Product Name: {1-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-4-phenyl-butyl}-carbamic acid tert-butyl ester
• CAS NO: 904324-81-8
• Molecular Weight: 486.614
• Mol File: 904324-81-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {1-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-4-phenyl-butyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {1-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-4-phenyl-butyl}-carbamic acid tert-butyl ester(904324-81-8)
• EPA Substance Registry System: {1-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-4-phenyl-butyl}-carbamic acid tert-butyl ester(904324-81-8)

Safety Data

• Hazardous Substances Data: 904324-81-8(Hazardous Substances Data)

Upstream product

• 666718-84-9 (1-hydroxymethyl-4-phenyl-butyl)-carbamic acid tert-butyl ester 
• 98628-27-4 2-tert-butoxycarbonylamino-5-phenyl-pentanoic acid 
• 552331-16-5 5-bromo-3-methyl-1H-indazole 
• 904324-66-9 [1-(5-bromo-pyridin-3-yloxymethyl)-4-phenyl-butyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase

Based on lead compounds 2 and 3 a series of 3,5-disubstituted pyridines have been designed and evaluated for inhibition of AKT/PKB. Modifications at the 3 position of the pyridine ring led to a number of potent compounds with improved physical properties, resulting in the identification of 11g as a promising, orally active Akt inhibitor. The synthesis, structure-activity relationship studies, and pharmacokinetic data are presented in this paper.