90434-92-7

Basic information

• Product Name: 4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOHYDRAZIDE
• Synonyms: 1H-indazole-3-carboxylic acid, 4,5,6,7-tetrahydro-, hydraz;Zinc03833224
• CAS NO: 90434-92-7
• Molecular Formula: C₈H₁₂N₄O
• Molecular Weight: 180.21104
• Mol File: 90434-92-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.331g/cm³
• Refractive Index: 1.629
• CAS DataBase Reference: 4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOHYDRAZIDE(90434-92-7)
• EPA Substance Registry System: 4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOHYDRAZIDE(90434-92-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 90434-92-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H12N4O/c9-10-8(13)7-5-3-1-2-4-6(5)11-12-7/h1-4,9H2,(H,10,13)(H,11,12)

Upstream product

• 4492-02-8 ethyl 4,5,6,7-tetrahydro-1H-indazole-3-carboxylate 
• 108-94-1 cyclohexanone 
• 5396-14-5 ethyl 2-oxo-2-(2-oxocyclohexyl)acetate 

Downstream Products

• 1381840-62-5 N'-[1-(2,4-dihydroxyphenyl)ethylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazone 
• 1381840-66-9 N'-[(3-chloro-4-hydroxy-5-methoxyphenyl)methylene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazone 
• 326018-40-0 N'-[(2-hydroxyphenyl)methylene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazone 
• 1381840-59-0 N'-[(4-cyanophenyl)methylene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazone 
• 303208-18-6 N'-[(2-hydroxynaphthalen-1-yl)methylene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazone 
• 1381840-61-4 N'-[(4-chloro-3-nitrophenyl)methylene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazone 
• 1381840-60-3 N'-[(4-chloro-3-fluorophenyl)methylene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazone 
• 331234-59-4 N'-[(2,4-dihydroxyphenyl)methylene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazone 
• 1477482-59-9 C₁₆H₁₈N₄O₂ 
• 1477482-57-7 C₁₅H₁₆N₄O₂ 
• 94000-49-4 4,5,6,7-tetrahydro-1⁽²⁾H-indazole-3-carboxylic acid benzylidenehydrazide 
• 92553-19-0 4,5,6,7-tetrahydro-1⁽²⁾H-indazole-3-carboxylic acid (4-chloro-benzylidene)-hydrazide 
• 1477482-50-0 C₁₆H₁₈N₄O 
• 1477483-16-1 C₁₇H₂₀N₄O₂ 

Relevant articles and documents

Indazole hydrazide compound and application thereof

The invention provides an indazole hydrazide compound as shown in a formula (I), wherein R is selected from substituted alkyl, substituted alkenyl or substituted phenyl; substituent groups in the substituted alkyl group and the substituted alkenyl group comprise phenyl and/or substituted phenyl; and R' is selected from H or alkyl. Compared with the prior art, the indole hydrazide compound provided by the invention can be used as an integrin avbeta3 receptor antagonist, has obvious anti-prostatic cancer activity, and has a significant inhibition effect on enzalutamide drug-resistant cell lines.

TUBULIN INHIBITORS

The present invention relates to a compound of Formula (I) for use as a medicament, wherein: m is 0, 1, 2, 3, 4, or 5; R1 and R2 together form a five-membered, six-membered, or seven-membered ring, wherein R1 and R2 together as a group is -(CH2)3-, -(CH2)4 -, or -(CH2)5-; R3 at each occurrence is independently selected from the group consisting of H, halogen, hydroxyl, alkoxy, and a substituted or unsubstituted C1-C5 alkyl; and R4 is H, halogen, or a substituted or unsubstituted C1-C5 alkyl