90455-12-2Relevant academic research and scientific papers
Asymmetric Catalysis of Ene-type Reaction with Fluoral by Chiral Titanium Complex: A Semi-empirical and Ab-initio Analysis of Ene Reactivity
Mikami, Koichi,Yajima, Tomoko,Terada, Masahiro,Uchimaru, Tadafumi
, p. 7591 - 7594 (1993)
The chiral titanium complex-catalyzed ene-type reaction with fluoral is shown to serve as an efficient route for the asymmetric synthesis of CF3-substituted compounds of biological and synthetic importance in extremely high enantiomeric excesses (>95perce
Lewis Acid Catalysis of Ene Addition of Chloral and Bromal to Olefins; Product Studies
Benner, Jill P.,Gill, G. Bryon,Parrott, Stephen J.,Wallace, Brian
, p. 291 - 313 (2007/10/02)
The addition of chloral and bromal to a variety of alkyl-substituted alkenes has been investigated.The effect of the reaction of varying the Lewis acid catalyst and the structure of substrate have been studied.Anhydrous AlCl3 was found to be most effective catalyst, and ene-type adducts were the major products in most cases.Side reactions were observed with the less reactive systems leading, variously, to the formation of trihalogenoketones, hydrohalogenated ene adducts, and cyclic ethers.Conditions for optimising the yield of ene adducts were established in some cases.The trihalogenoketone by-products can be conveniently removed by a Grignard-type reaction.
