EC 3.4.22.1, also known as Cathepsin B, is a lysosomal cysteine proteinase that hydrolyzes proteins with a broad specificity for peptide bonds. It is found in human liver and plays a crucial role in various biological processes, including apoptosis induction and proteolysis.
9047-22-7
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Basic information
- Product Name: Cathepsin B
- Synonyms: CATHEPSIN B;CATHEPSIN B1, BOVINE SPLEEN;CATHEPSIN B, BOVINE SPLEEN;EC 3.4.22.1;CATHEPSIN B FROM HUMAN LIVER;CATHEPSIN B FROM HUMAN PLACENTA;CATHEPSIN B FROM BOVINE SPLEEN;CathepsinB from human placenta,CathepsinB1
- CAS NO:9047-22-7
- Molecular Formula: NULL
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /lyophilized powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: H2O: soluble1.0mg/mL, clear
- CAS DataBase Reference: Cathepsin B(CAS DataBase Reference)
- NIST Chemistry Reference: Cathepsin B(9047-22-7)
- EPA Substance Registry System: Cathepsin B(9047-22-7)
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Safety Data
- Hazard Codes: B
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS: FI5725000
- F: 10-21
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9047-22-7(Hazardous Substances Data)
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9047-22-7 Usage
Uses
Used in Research Applications:EC 3.4.22.1 is used as a positive control in the screening of Cathepsin B inhibitor assays, helping researchers identify potential inhibitors of this enzyme.
Used in Wall Extension Assays:
EC 3.4.22.1 is used as an expansin activity assay to study the effects of this enzyme on cell wall extension and remodeling.
Used in Apoptosis Induction Studies:
EC 3.4.22.1 is used in microinjection of human foreskin fibroblasts to test its effect on apoptosis induction, providing valuable insights into the mechanisms of programmed cell death.
Used in Alzheimer's Research:
Cathepsin B may be a useful tool in Alzheimer's research, as it may have a role in the natural defense against the disease.
Used in Caspase Activation:
EC 3.4.22.1 may be used to cleave procaspase 1 and procaspase 11, contributing to the activation of caspases and the induction of apoptosis in digitonin-permeabilized cells.
Biochem/physiol Actions
Cathepsin B displays an endopeptidase and peptidyl dipeptidase activities. It may be associated with the pathophysiology of tumors. Cathepsin B is also regarded as a prominent protease in Leishmaniasis. It is overactivated in muscular dystrophy, pulmonary emphysema, and bone resorption.Purification Methods
Cathepsin B is purified by affinity chromatography on the semicarbazone of Gly-Phe-glycinal-linked to Sepharose 4B, with elution by 2,2'-dipyridyl disulfide [Rich et al. Biochem J 235 731 1986, Methods Enzymol 80 551 1981].Check Digit Verification of cas no
The CAS Registry Mumber 9047-22-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,4 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.Calculate Digit Verification of CAS Registry Number 9047-22:
(6*9)+(5*0)+(4*4)+(3*7)+(2*2)+(1*2)=97
97 % 10 = 7
So 9047-22-7 is a valid CAS Registry Number.
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Cathepsin B
