90472-68-7Relevant academic research and scientific papers
Enzymes in Organic Synthesis, 8: Synthesis of Enantiomerically Pure Prostaglandin Intermediates by Enzymatic Transesterification of (1S*,5R*,6R*,7R*)-(+/-)-7-Hydroxy-6-hydroxymethyl-2-oxabicyclooctan-3-one
Weidner, Judith,Theil, Fritz,Kunath, Annamarie,Schick, Hans
, p. 1301 - 1304 (2007/10/02)
Lipase Amano PS is a suitable biocatalyst for the highly regio- and enantioselective transesterification of the racemic prostaglandin building block (1S*,5R*,6R*,7R*)-(+/-)-7-hydroxy-6-hydroxymethyl-2-oxabicyclooctan-3-one (rac-1) yielding (1S,5R,6R,7R)-(-)-6-acetoxymethyl-7-hydroxy-2-oxabicyclooctan-3-one (2) and the unreacted (1R,5S,6S,7S)-(+)-enantiomer ent-1.Key Words: Prostaglandin intermediates / Enzymatic transformations / Lipases in organic solvents
