90481-43-9

Usage

Appearance

Dark red or brown solid

Uses

a. Manufacture of dyes and pigments
b. Absorbing ultraviolet light in sunscreen and skin care products
c. Fluorescent dye in biological research
d. Inhibitor of tyrosinase, an enzyme involved in melanin production

Hazards

a. Hazardous if ingested
b. Hazardous if inhaled
c. Hazardous if it comes into contact with the skin

Safety precautions

Handle with care to avoid ingestion, inhalation, or skin contact

Upstream product

• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 137-07-5 2-amino-benzenethiol 
• 6265-93-6 2-(2′-hydroxy-3′-methoxyphenyl)benzothiazole 
• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 883-93-2 2-Phenylbenzothiazole 
• 303-38-8 2,3-Dihydroxybenzoic acid 

Relevant academic research and scientific papers

Product-boosted fluorescence signal: A new approach for designing small-molecule probes for detection of peroxynitrite

In situ self-assembled boronate ester comprising commercially available 2-formylphenylboronic acid and 2-(2′,3′-bihydroxyphenyl)benzothiazole (BHBT) is explored for the detection of ONOO- with product-boosted fluorescence. The self-assembly can detect ONO

The invention relates to a thiazole as a matrix of the acrylic ester compound as the fluorescent probe application and its preparation method (by machine translation)

The invention relates to a thiazole as a matrix of the acrylic ester compound as the fluorescent probe application and its preparation method, the preparation of the fluorescent probe BTHA in dimethyl sulfoxide and 4 - hydroxyethyl piperazine ethyl sulfon

Antidiabetic potential and enzyme kinetics of benzothiazole derivatives and their non-bonded interactions with α-glucosidase and α-amylase

Benzothiazole derivatives were synthesized and their antidiabetic potential evaluated using α-glucosidase, α-amylase, non-enzymatic glycosylation of hemoglobin and advanced glycation end product inhibition assays. Compound 3l showed low IC50 va

The immunomodulation potential of the synthetic derivatives of benzothiazoles: Implications in immune system disorders through in vitro and in silico studies

Benzothiazole and its natural or synthetic derivatives have been used as precursors for several pharmacological agents for neuroprotective, anti-bacterial, and anti-allergic activities. The objecctive of the present study was to evaluate effects of benzot

Antileishmanial activities of benzothiazole derivatives

Benzothiazole derivatives 1-22 were synthesized from 2-aminothiophenol and all synthetic compounds were screened for in vitro antileishmanial activity. These compound showed different types activities against leishmania with IC50 values ranging

IMMUNOSUPPRESSIVE COMPOUNDS

The invention feature series of benzothiazole derivatives as potent immunosuppressive and antiinflammatory agents. Eight compounds 2, 4, 5, 8, 9, 10, 12, and 18 showed potent inhibitory activity on PHA-activated T-cell proliferation. Compounds 2, 4, 8, and 18 were found to have a potent inhibitory activity with IC50 values ranging 50 values 1.9, 5050), respectively.

A ball-milling strategy for the synthesis of benzothiazole, benzimidazole and benzoxazole derivatives under solvent-free conditions

A convenient solvent-free method for the synthesis of benzothiazole, benzimidazole, and benzoxazole derivatives has been developed using recyclable ZnO-NPs via a ball-milling strategy. The method affords environmentally friendly reaction conditions that score high on the ecoscale with the low E-factor. The process is also highly efficient even on a multi-gram scale and provides easy product isolation.

Visible-light-driven synthesis of 2-substituted benzothiazoles using CdS nanosphere as heterogenous recyclable catalyst

This Letter reports simple, green, and efficient synthesis of mesoporous CdS nanosphere (CdSNS) and its application as heterogeneous catalyst for the synthesis of 2-substituted benzothiazole. We report, for the first time, the synthesis of 2-substituted benzothiazoles from various aryl and alkyl aldehydes under visible light irradiation at room temperature. CdSNS catalyst generated in water demonstrates excellent catalytic activity for both the alkyl and aryl aldehydes, with good recyclability. The reaction yield is high for the electron-donating and electron withdrawing substituents as well as heterocyclic aldehydes with good turn over number (TON) and turnover frequency (TOF).

Synthesis of vicinal diols from various arenes with a heterocyclic, amino or carboxyl group by using recombinant Escherichia coli cells expressing evolved biphenyl dioxygenase and dihydrodiol dehydrogenase genes

Various aromatic molecules, in which heterocycles are linked with a phenyl or benzyl group, were converted to their respective 2,3-diols (catechols) in the benzene ring by growing cell reactions using recombinant Escherichia coli, which expressed the evolved biphenyl dioxygenase [bphA (2072)] genes and the subsequent bacterial dihydrodiol dehydrogenase (bphB) gene. These vicinal diol products showed strong in vitro inhibitory activity against the lipid peroxidation induced by free radicals and strong scavenging activity towards DPPH radicals. The vicinal diols were also synthesized from ionized monocyclic aromatics incorporating an amino or carboxyl group. Graphical abstract.

Solid-state Fluorescent Photophysics of Some 2-Substituted Benzothiazoles

The solid-state fluorescence properties of a series of benzothiazoles with phenyl, napthalene, and coumarin moieties substituted at the 2-position have been investigated.The necessity for a 2'-OH substituent for fluorescence has been confirmed and the effects of further substitution in the 2-phenyl ring are reported.