904894-54-8

Basic information

• Product Name: Zoledronic Acid Trihydrate
• Synonyms: Zoledronic Acid Trihydrate;1-Hydroxy-2-(1H-iMidazol-1-yl)ethylidene]-bisphosphonic Acid Trihydrate;2-(IMidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic Acid Trihydrate
• CAS NO: 904894-54-8
• Molecular Formula: C5H10N2O7P2
• Molecular Weight: 272.089622
• Product Categories: Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
• Mol File: 904894-54-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 232-235°C (dec.)
• Appearance: /
• Storage Temp.: Refrigerator
• CAS DataBase Reference: Zoledronic Acid Trihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Zoledronic Acid Trihydrate(904894-54-8)
• EPA Substance Registry System: Zoledronic Acid Trihydrate(904894-54-8)

Safety Data

• Hazardous Substances Data: 904894-54-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Bisphosphonate antiresorptive agent.

Upstream product

• 118072-93-8 1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid 
• 22884-10-2 imidazol-1-ylacetic acid 
• 165800-06-6 zoledronic acid monohydrate 

Relevant articles and documents

Efficient syntheses of zoledronic acid as an active ingredient of a drug against osteoporosis

The reaction of 1H-imidazol-1-ylacetic acid and two equivalents of phosphorus trichloride/phosphorous acid at 75 °C in sulfolane, or in the presence of catalytic amounts of [bmim][BF4] afforded zoledronic acid in yields up to 75%. The joint use of the ionic liquid additive and sulfolane as the solvent was synergetic affording highly valuable zoledronic acid in a record yield of 93%.

A CRYSTALLINE FORM OF THE ZOLEDRONIC ACID, A PROCESS TO OBTAIN IT AND THE PHARMACEUTICAL COMPOSITION COMPRISING IT

This invention refers to a new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.

Crystalline form of zoledronic acid

Zoledronic acid trihydrate.