904914-14-3Relevant articles and documents
The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production
Sabat, Mark,VanRens, John C.,Clark, Michael P.,Brugel, Todd A.,Maier, Jennifer,Bookland, Roger G.,Laufersweiler, Matthew J.,Laughlin, Steven K.,Golebiowski, Adam,De, Biswanath,Hsieh, Lily C.,Walter, Richard L.,Mekel, Marlene J.,Janusz, Michael J.
, p. 4360 - 4365 (2007/10/03)
A series of C-2, C-8, and N-9 trisubstituted purine based inhibitors of TNF-α production are described. The most potent analogs showed low nanomolar activity against LPS-induced TNF-α production in a THP-1 cell based assay. The SAR of the series was optim