905-52-2

Basic information

• Product Name: 11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3)
• CAS NO: 905-52-2
• Molecular Weight: 344.451
• Mol File: 905-52-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3)(CAS DataBase Reference)
• NIST Chemistry Reference: 11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3)(905-52-2)
• EPA Substance Registry System: 11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3)(905-52-2)

Safety Data

• Hazardous Substances Data: 905-52-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
11β,17β-Dihydroxy-17α-acetyl-androstadien-(1,4)-on-(3) is used as a key intermediate in the synthesis of Prednisolone (P703740), a synthetic corticosteroid. Prednisolone exhibits potent anti-inflammatory and immunosuppressive properties, making it a valuable drug for treating a wide range of conditions, including autoimmune disorders, allergies, and inflammatory diseases. Its use in pharmaceuticals is primarily due to its ability to modulate the immune system and reduce inflammation, providing relief and managing symptoms in various medical conditions.

Upstream product

• 30934-01-1 17α-Hydroxy-pregna-1,4,9(11)-dien-3,20-dion 

Relevant articles and documents

A process for the preparation of prednisolone

The application relates to a method for synthetizing prednisolone. Double bond bromination, reductive debromination, bromination and hydrolysis reaction are carried out on a compound with a structure of formula I so as to generate the prednisolone. The method is high in yield, is easy to operate, and is applicable to industrial production.

Process for the preparation of 21-desoxy-17-acyloxy-4-pregnenes and of 21-iodo-21-desoxy-17-acyl oxy-4-pregnene intermediates useful therein

21-Desoxy-17α-acyloxy-20-keto-4-pregnenes having physiological properties are prepared by the reaction of a 17α,21-dihydroxy-20-keto-4-pregnene 17α,21-orthoester or a 21-iodo-21-desoxy-17α-acyloxy-20-keto-4-pregnene with an iodide reagent selected from the group consisting of triphenylsilyl iodide, tri-lower alkylsilyl iodide and triphenylmethyl iodide. When said 17α,21-dihydroxy-20-keto-4-pregnene 17α,21-orthoester is reacted with less than two molar equivalents of a tri-lower alkylsilyl iodide reagent there is also formed a 21-iodo-21-desoxy-17-α -acyloxy-20-keto-4-pregnene, a useful intermediate, which, upon reaction with additional iodide reagent, is converted to the corresponding 21-desoxy-17α-acyloxy-20-keto-4-pregnene.