90521-13-4Relevant academic research and scientific papers
Antitumor Imidazotetrazines. 20. Preparation of the 8-Acid Derivative of Mitozolomide and Its Utility in the Preparation of Active Antitumor Agents
Horspool, K. R.,Stevens, M. F. G.,Newton, C. G.,Lunt, E.,Walsh, R. J. A.,et al.
, p. 1393 - 1399 (2007/10/02)
The preparation of 3-(2-chloroethyl)-4-oxo-3H-imidazo-1,2,3,5-tetrazine-8-carboxylic acid, a key derivative of mitozolomide in our exploration of the structure-activity relationships of this class of antitumor agents, is described.The facile conver
Antitumor Imidazotetrazines. 14. Synthesis and Antitumor Activity of 6- and 8-Ssubstituted Imidazo-1,2,3,5-tetrazinones and 8-Substituted Pyrazolo-1,2,3,5-tetrazinones
Lunt, Edward,Newton, Christopher G.,Smith, Christopher,Stevens, Graham P.,Stevens, Malcolm F. G.,et al.
, p. 357 - 366 (2007/10/02)
The systematic variation of the potent antitumor agent mitozolomide (1) is extended to cover alteration of substituents at position 6 and 8 and to change the imidazo-1,2,3,5-tetrazinone (6) skeleton to the isomeric pyrazolo-1,2,3,5-tetrazino
