905281-83-6Relevant academic research and scientific papers
Non-oxime pyrazole based inhibitors of B-Raf kinase
Newhouse, Bradley J.,Hansen, Joshua D.,Grina, Jonas,Welch, Mike,Topalov, George,Littman, Nicole,Callejo, Michele,Martinson, Matthew,Galbraith, Sarah,Laird, Ellen R.,Brandhuber, Barbara J.,Vigers, Guy,Morales, Tony,Woessner, Rich,Randolph, Nikole,Lyssikatos, Joseph,Olivero, Alan
, p. 3488 - 3492 (2011/06/24)
The synthesis and biological evaluation of non-oxime pyrazole based B-Raf inhibitors is reported. Several oxime replacements have been prepared and have shown excellent enzyme activity. Further optimization of fused pyrazole 2a led to compound 38, a selec
RAF INHIBITOR COMPOUNDS AND METHODS
-
Page/Page column 84, (2008/06/13)
Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
