166196-54-9

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-Bromo-1H-pyrazol-3-yl)pyridine is used as a key intermediate in the synthesis of pharmaceuticals for its potential applications in medicinal chemistry and drug discovery. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(4-Bromo-1H-pyrazol-3-yl)pyridine serves as a crucial building block in the creation of novel agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, thereby supporting sustainable agriculture.
Used in Organic Synthesis:
4-(4-Bromo-1H-pyrazol-3-yl)pyridine is utilized as a versatile intermediate in organic synthesis, enabling the production of a wide range of organic compounds. Its chemical and physical properties make it an ideal candidate for various synthetic pathways, broadening its applications in research and industry.
Used in Research and Development:
4-(4-Bromo-1H-pyrazol-3-yl)pyridine is also employed in research and development settings, where its unique structure and reactivity are harnessed to explore new chemical reactions and mechanisms. This contributes to the expansion of scientific knowledge and the discovery of innovative applications in various fields.

Upstream product

• 17784-60-0 4-(1H-pyrazol-3-yl)pyridine 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 123367-27-1 (E)-3-(dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one 

Downstream Products

• 905281-83-6 benzyl 4-(4-bromo-3-(pyridin-4-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1314259-23-8 2-chloro-5-[1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]benzoic acid 
• 1314264-36-2 2-chloro-5-[1-(2-hydroxyethyl)-3-pyridin-4-yl-1H-pyrazol-4-yl]benzoic acid methyl ester 

Relevant academic research and scientific papers

Potent and selective pyrazole-based inhibitors of B-Raf kinase

Herein we describe a novel pyrazole-based class of ATP competitive B-Raf inhibitors. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. A subset of these inhibitors has demonstrated the ability to inhibit downstream ERK phosphorylation in LOX tumors from mouse xenograft studies.

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis

Phenotypic whole cell high-throughput screening of a μ150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide 1 as a moderately active hit. Structure-activity

RAF INHIBITOR COMPOUNDS AND METHODS

Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.