166196-54-9

Basic information

• Product Name: 4-(4-bromo-1H-pyrazol-3-yl)pyridine
• Synonyms: 4-(4-bromo-1H-pyrazol-3-yl)pyridine;4-(4-bromo-1H-pyrazol-5-yl)pyridine(SALTDATA: FREE);4-(4-Bromo-1h-pyrazol-3-yl)pyridin;Pyridine, 4-(4-bromo-1H-pyrazol-3-yl)-
• CAS NO: 166196-54-9
• Molecular Formula: C₈H₆BrN₃
• Molecular Weight: 224.06
• Mol File: 166196-54-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 381.2 °C at 760 mmHg
• Flash Point: 184.4 °C
• Appearance: /
• Density: 1.651
• Storage Temp.: 2-8°C
• PKA: 10.55±0.50(Predicted)
• CAS DataBase Reference: 4-(4-bromo-1H-pyrazol-3-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-bromo-1H-pyrazol-3-yl)pyridine(166196-54-9)
• EPA Substance Registry System: 4-(4-bromo-1H-pyrazol-3-yl)pyridine(166196-54-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 166196-54-9(Hazardous Substances Data)

Usage

General Description

4-(4-Bromo-1H-pyrazol-3-yl)pyridine is a chemical compound with the molecular formula C9H6BrN3. It is a heterocyclic compound that consists of a pyridine ring attached to a pyrazol ring with a bromine substituent. 4-(4-Bromo-1H-pyrazol-3-yl)pyridine is often used as a building block or intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has potential applications in medicinal chemistry and drug discovery due to its unique structure and reactivity. 4-(4-Bromo-1H-pyrazol-3-yl)pyridine has various chemical and physical properties that make it a valuable and versatile compound for research and industrial purposes.

Upstream product

• 123367-27-1 (E)-3-(dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 17784-60-0 4-(1H-pyrazol-3-yl)pyridine 

Downstream Products

• 1314259-23-8 2-chloro-5-[1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]benzoic acid 
• 1314264-36-2 2-chloro-5-[1-(2-hydroxyethyl)-3-pyridin-4-yl-1H-pyrazol-4-yl]benzoic acid methyl ester 
• 905281-83-6 benzyl 4-(4-bromo-3-(pyridin-4-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 

Relevant articles and documents

Potent and selective pyrazole-based inhibitors of B-Raf kinase

Herein we describe a novel pyrazole-based class of ATP competitive B-Raf inhibitors. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. A subset of these inhibitors has demonstrated the ability to inhibit downstream ERK phosphorylation in LOX tumors from mouse xenograft studies.

RAF INHIBITOR COMPOUNDS AND METHODS

Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.