905285-01-0Relevant academic research and scientific papers
Direct access to marine pyrrole-2-aminoimidazoles, oroidin, and derivatives, via new acyl-1,2-dihydropyridin intermediates
Schroif-Gregoire, Cosima,Travert, Nathalie,Zaparucha, Anne,Al-Mourabit, Ali
, p. 2961 - 2964 (2007/10/03)
A short synthesis of the C11N5 oroidin derivatives is reported. The key step of the strategy is a one-pot oxidative bromine-mediated addition of protected guanidines to the N-acyl-1,2-dihydropyridines 9a-c. The new N-acyl-1,2-dihydropyridines were prepared directly from pyridine and pyrrole-2-carbonyl chloride by reduction with borohydride reagent in one step.
