905291-15-8

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 109765-52-8 3-bromo-2-hydroxy-4,5-dimethoxybenzaldehyde 
• 14382-91-3 2-hydroxy-4,5-dimethoxybenzaldehyde 
• 4460-86-0 asaraldehyde 

Downstream Products

• 905291-20-5 C₂₃H₃₃BrO₄ 
• 905291-19-2 C₂₆H₄₁BrO₄Si 
• 874194-38-4 [3-bromo-2-(tert-butyl-dimethyl-silanyloxy)-4,5-dimethoxy-phenyl]-methanol 

Relevant academic research and scientific papers

Synthesis of phosphatidylinositol 3-kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal

Analogues of the sponge meroterpenoid liphagal (1) have been synthesized and evaluated for inhibition of PI3Kα and PI3Kα as part of a program aimed at developing new isoform-selective PI3K inhibitors. One of the analogues, compound 24, with IC50/sub

Liphagal, a selective inhibitor of PI3 kinase α isolated from the sponge Aka coralliphaga: Structure elucidation and biomimetic synthesis

Liphagal (1), a selective inhibitor of PI3K α, has been isolated from the marine sponge Aka coralliphaga collected in Dominica. The "liphagane" meroterpenoid carbon skeleton of liphagal (1) is new. A biomimetic total synthesis has been used to confirm the

MEROTERPENOID INHIBITORS OF PHOSPHOINOSITIDE 3 KINASE (PI3K)

Compounds with unique liphagane meroterpenoid carbon skeleton are described (structures I, II, III) together with pharmaceutical compositions and their use. A method of inhibiting the activity of phosphoinositide 3 kinase (PBK) is disclosed. In particular