905291-20-5Relevant articles and documents
Synthesis of phosphatidylinositol 3-kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal
Pereira, Alban R.,Strangman, Wendy K.,Marion, Frederic,Feldberg, Larry,Roll, Deborah,Mallon, Robert,Hollander, Irwin,Andersen, Raymond J.
, p. 8523 - 8533 (2011/02/26)
Analogues of the sponge meroterpenoid liphagal (1) have been synthesized and evaluated for inhibition of PI3Kα and PI3Kα as part of a program aimed at developing new isoform-selective PI3K inhibitors. One of the analogues, compound 24, with IC50/sub
MEROTERPENOID INHIBITORS OF PHOSPHOINOSITIDE 3 KINASE (PI3K)
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Page/Page column 32-34; 37, (2008/06/13)
Compounds with unique liphagane meroterpenoid carbon skeleton are described (structures I, II, III) together with pharmaceutical compositions and their use. A method of inhibiting the activity of phosphoinositide 3 kinase (PBK) is disclosed. In particular