905309-75-3

Upstream product

• 186193-09-9 allyl (2S)-2-({3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropanoyl}oxy)-4-methylpentanoate 
• 180181-02-6 3-(tert-Butoxycarbonyl)amino-2,2-dimethylpropanoic Acid 
• 195387-08-7 methyl 3-<<(tert-butoxy)carbonyl>amino>-2,2-dimethylpropanoate 
• 704870-54-2 methyl (2R)-2-amino-3-(3-chloro-4-methoxyphenyl)propanoate 
• 162465-44-3 methyl (2R)-2-[(tert-butoxycarbonyl)amino]-3-(3-chloro-4-methoxyphenyl)propanoate 
• 478183-57-2 (2R)-2-[(tert-butoxycarbonyl)amino]-3-(3-chloro-4-hydroxyphenyl)propanoic acid 
• 162465-33-0 allyl (2S)-2-Hydroxy-4-methylpentanoate 
• 556-02-5 tyrosine 
• 13748-90-8 (S)-2-hydroxyl-3,3-dimethylbutyric acid 
• 61-90-5 L-leucine 
• 905309-67-3 allyl (2S)-2-({3-[(N-acryloyl-3-chloro-O-methyl-D-tyrosyl)amino]-2,2-dimethylpropanoyl}oxy)-4-methylpentanoate 
• 905309-66-2 (1Z,4S)-1-iodo-1-phenylhepta-1,6-dien-4-ol 
• 905309-77-5 (1S,3Z)-1-allyl-4-iodo-4-phenylbut-3-enyl (2S)-2-({3-[(N-acryloyl-3-chloro-O-methyl-D-tyrosyl)amino]-2,2-dimethylpropanoyl}oxy)-4-methylpentanoate 
• 905309-58-2 (2R)-2-(acryloylamino)-3-(3-chloro-4-methoxyphenyl)propanoic acid 

Relevant academic research and scientific papers

Total synthesis of cryptophycin analogues via a scaffold approach

Allylation of in situ generated β,γ-unsaturated aldehydes affords rapid access to vinyl halide analogues of fragment A of the cryptophycins. Three scaffolds are prepared in gram quantities by a ring-closing metathesis approach. Derivatization via a variety of cross-coupling protocols is possible, which affords novel analogues of these potent antimitotic agents.