90531-75-2

Usage

Uses

Used in Pharmaceutical Industry:
Benzoyl chloride, 4-(hydroxymethyl)-, is used as a reagent in the synthesis of various organic compounds for the development of new pharmaceuticals. Its unique functional group allows for the modification of the reactivity and properties of the compound, enabling the creation of innovative and effective drugs.
Used in Fragrance Industry:
In the fragrance industry, benzoyl chloride, 4-(hydroxymethyl)-, is utilized as a key component in the production of various scent compounds. Its ability to modify the reactivity and properties of other compounds contributes to the creation of unique and diverse fragrances.
Used in Dye Industry:
Benzoyl chloride, 4-(hydroxymethyl)-, is employed in the dye industry for the synthesis of various dye compounds. Its functional group plays a crucial role in the development of new dyes with improved properties and applications.
Overall, the versatility of benzoyl chloride, 4-(hydroxymethyl)-, in modifying the reactivity and properties of compounds makes it an essential component in various industries, particularly in the development of new pharmaceuticals, fragrances, and dyes.

Upstream product

• 3006-96-0 3-hydroxymethyl-benzoic acid 
• 589-18-4 4-Methylbenzyl alcohol 

Downstream Products

• 83231-35-0 4-Hydroxymethyl-benzoic acid 2-hydroxy-3-isopropylamino-propyl ester 
• 83231-40-7 4-Hydroxymethyl-benzoic acid 3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propyl ester 
• 1450753-76-0 N-tert-butyl-4-(hydroxymethyl)-2-(4-nitrobenzamido)benzamide 
• 1194752-89-0 N-tert-butyl-4-(hydroxymethyl)benzamide 
• 1370010-40-4 C₂₁H₂₀F₃N₃O₂S 
• 1220708-86-0 (4-(5-(butylamino)-1,3,4-thiadiazol-2-yl)phenyl)methanol 

Relevant academic research and scientific papers

Preparation method of 4-chloromethyl benzoyl chloride

The invention discloses a preparation method of 4-chloromethyl benzoyl chloride, wherein the preparation method comprises the steps: (1) a step of undergoing a chlorination reaction of 4-methylebnzenemethanol with chlorine gas under the action of a catalyst dibenzoyl peroxide to prepare a 4-hydroxymethyl trichlorobenzene crude product; (2) a step of undergoing a hydrolysis reaction of the 4-hydroxymethyl trichlorobenzene crude product prepared in the step (1) with water; and (3) a step of undergoing an acylation reaction of the hydrolysis product of the step (2) with excessive oxaloyl chlorideunder the action of a catalyst DMF, to prepare the target product 4-chloromethyl benzoyl chloride. The process has the advantages of easy availability of raw materials, low price, simple operation, fewer side reactions in the whole process, low energy consumption, high product quality, low product cost, and fewer three wastes; the total product yield is 85-90% and the purity is 99% or more.

C-F bond cleavage enabled redox-neutral [4+1] annulation via C-H bond activation

Using α,α-difluoromethylene alkyne as a nontraditional one-carbon reaction partner, a synthetically novel method for the construction of isoindolin-1-one derivatives via Rh(III)-catalyzed [4+1] annulation reaction is reported. The 2-fold C-F bond cleavage not only enables the generation of desired product under an overall oxidant-free condition but also results in a net migration of carbon-carbon triple bond. In addition, the present reaction protocol exhibits a tolerance of a wide spectrum of functional groups due to the mild reaction conditions employed.