90533-51-0Relevant academic research and scientific papers
N - heterocyclic compound, intermediate, preparation method, pharmaceutical composition and application (by machine translation)
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Paragraph 0354; 0355; 0357; 0358, (2017/10/31)
The invention discloses a N - heterocyclic compound, intermediate, preparation method, pharmaceutical composition and application. The invention of SHP2 N - heterocyclic compound to have high selectivity, can effectively inhibit the cell in the SHP2 downstream signal path ERK phosphorylation level, to tumor cells has very good inhibition activity, it has broad drug development prospects; its preparation method is simple, mild reaction conditions, high yield and purity, after treatment is simple, environmental protection, and is favorable for industrial production. (by machine translation)
