905459-67-8

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 89204-93-3 5-(4-chlorophenyl)oxazole-4-carboxylic acid methyl ester 
• 93102-91-1 2-amino-3-(4-chlorophenyl)-3-oxopropionic acid methyl ester hydrochloride 
• 106732-63-2 2-acetylamino-3-(4-chlorophenyl)-3-oxopropionic acid methyl ester 

Downstream Products

• 905459-69-0 [5-(4-chloro-phenyl)-2-methyl-thiazol-4-yl]-methanol 

Relevant academic research and scientific papers

1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to novel azetidine compounds of formula (I), wherein R1, R2, and X are as described in the description and their use as orexin receptor antagonists.

3-AZA-BICYCLO[3.3.0]OCTANE COMPOUNDS

The invention relates to 3-aza-bicyclo[3.3.0]octane derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as orexin receptor antagonists.

1,2-DIAMIDO-ETHYLENE DERIVATIVES

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) NHNR 3 OAOR 1 R 2 (I) wherein R1, R 2, R 3, and A are as described in the description and their use as medicaments, especially as orexin receptor

Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: Structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109

Following the discovery of a new series of benzimidazole derivatives bearing a diarylmethyl group as inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase (HCV NS5B RdRp), we extended the structure-activity relationship (SAR) study to analogue