905486-98-8Relevant academic research and scientific papers
2-Amino- and 2-alkylthio-4H-3,1-benzothiazin-4-ones: Synthesis, interconversion and enzyme inhibitory activities
Haecker, Hans-Georg,Grundmann, Florian,Lohr, Friederike,Ottersbach, Philipp A.,Zhou, Jing,Schnakenburg, Gregor,Guetschow, Michael
experimental part, p. 378 - 402 (2009/09/05)
The synthetic access to 2-sec-amino-4H-3,1-benzothiazin-4-ones 2 was explored. Compounds 2 were available from methyl 2-thioureidobenzoates 1, 2-thioureidobenzoic acids 3, and novel 2-thioureidobenzamides 6, respectively, under different conditions. 2-Alk
Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: Synthesis, biological evaluation, and structure - Activity relationships
H?cker, Hans-Georg,Leyers, Stefan,Wiendlocha, Jeanette,Gütschow, Michael,Wiese, Michael
supporting information; scheme or table, p. 4586 - 4595 (2010/03/03)
Four series of aromatic carboxylic acids were prepared with a urea or thiourea moiety at the neighboring position to the carboxyl group and benzene or thiophene as aromatic scaffold. Using a calcein AM assay, these compounds were evaluated as inhibitors o
