90553-43-8

Basic information

• Product Name: N-[(5-BROMOTHIEN-2-YL)METHYL]-N-METHYLAMINE
• Synonyms: 5-BroMo-N-Methyl-2-thiopheneMethanaMine
• CAS NO: 90553-43-8
• Molecular Formula: C₆H₈BrNS
• Molecular Weight: 206.1
• Mol File: 90553-43-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 230.9°Cat760mmHg
• Flash Point: 93.5°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.064mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: N-[(5-BROMOTHIEN-2-YL)METHYL]-N-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(5-BROMOTHIEN-2-YL)METHYL]-N-METHYLAMINE(90553-43-8)
• EPA Substance Registry System: N-[(5-BROMOTHIEN-2-YL)METHYL]-N-METHYLAMINE(90553-43-8)

Safety Data

• Hazardous Substances Data: 90553-43-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H8BrNS/c1-8-4-5-2-3-6(7)9-5/h2-3,8H,4H2,1H3/p+1

Upstream product

• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 740042-80-2 1-(4-Bromo-phenyl)-2-[(5-bromo-thiophen-2-ylmethyl)-methyl-amino]-ethanol 
• 758642-08-9 2-[(5-Bromo-thiophen-2-ylmethyl)-methyl-amino]-1-p-tolyl-ethanol 
• 765227-25-6 2-[(5-Bromo-thiophen-2-ylmethyl)-methyl-amino]-1-phenyl-ethanol 
• 82230-39-5 2-bromo-4-(4-bromo-phenyl)-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine 
• 88013-69-8 2-bromo-4-(p-methylphenyl)-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine 
• 82230-38-4 2-bromo-6-methyl-4-phenyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine 

Relevant articles and documents

Elimination reactions of N-alkyl-N-chlorothenylamines promoted by MeONa-MeOH and Et2NH-MeCN. Effect of the β-aryl group on the imine-forming transition state

Elimination reactions of N-alkyl-N-chlorothenylamines 1-4 with MeONa-MeOH and Et2NH-MeCN have been studied kinetically. The elimination reactions are regiospecific, producing only the conjugated imines. The reactions are second order and exhibit substantial values of Hammett ρ and k H/kD, and an E2 mechanism is evident. The relative rates of elimination for Me/Et/i-Pr/i-Bu substituents are 1/0.5/0.2/0.02 with MeONa-MeOH and 1/0.4/0.2/0.06 with Et2NH-MeCN. The transition state structure changes toward more product-like as the base is changed from MeONa-MeOH to Et2NH-MeCN. Comparison with existing data reveals that the structure of the transition state is relatively insensitive to the β-aryl group variation.