905567-14-8Relevant articles and documents
Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist
Lund, Birgitte W.,Piu, Fabrice,Gauthier, Natalie K.,Eeg, Anne,Currier, Erika,Sherbukhin, Vladimir,Brann, Mark R.,Hacksell, Uli,Olsson, Roger
, p. 7517 - 7519 (2005)
4′-Octyl-4-biphenylcarboxylic acid (1g, AC-55649) was identified as a highly isoform-selective agonist at the human RARβ2 receptor in a functional intact cell-based screening assay. The subsequent hit to lead optimization transformed the lipophilic, poorl