90557-92-9

Basic information

• Product Name: 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOHYDRAZIDE
• Synonyms: 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOHYDRAZIDE;1,4-BENZODIOXAN-2-CARBOXYLIC ACID HYDRAZIDE
• CAS NO: 90557-92-9
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.1873
• Mol File: 90557-92-9.mol

Chemical Properties

• Boiling Point: 417.4°Cat760mmHg
• Flash Point: 206.2°C
• Appearance: /
• Density: 1.333g/cm³
• Vapor Pressure: 3.55E-07mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOHYDRAZIDE(90557-92-9)
• EPA Substance Registry System: 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOHYDRAZIDE(90557-92-9)

Safety Data

• Hazardous Substances Data: 90557-92-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dihydro-1,4-benzodioxine-2-carbohydrazide is used as a pharmaceutical agent for its potential antitumor and antiviral properties. It has shown promise in the development of new drugs and therapies for the treatment of various diseases.
Used in Chemical Synthesis:
2,3-Dihydro-1,4-benzodioxine-2-carbohydrazide is used as a reagent in organic synthesis for the preparation of other chemical compounds. Its unique structure and properties make it a valuable building block in the synthesis of various organic molecules.
Used in Industrial Manufacturing:
2,3-Dihydro-1,4-benzodioxine-2-carbohydrazide is used in industrial manufacturing for the production of various chemical products. Its versatility and potential applications in different industries make it a valuable component in the manufacturing process.

InChI:InChI=1/C9H10N2O3/c10-11-9(12)8-5-13-6-3-1-2-4-7(6)14-8/h1-4,8H,5,10H2,(H,11,12)/t8-/m1/s1

Upstream product

• 4739-94-0 ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate 
• 3663-79-4 methyl 2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate 
• 3663-80-7 1,4-benzodioxane-2-carboxylic acid 
• 120-80-9 benzene-1,2-diol 

Downstream Products

• 1172418-19-7 2-(3-methyl-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3 4-oxadiazole 
• 1292770-61-6 2-(4-hydroxy-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole 
• 1171941-68-6 2-(2-bromo-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole 
• 350046-93-4 N'-[3-hydroxy-4-methoxyphenyl-methylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide 
• 1370413-81-2 N-(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 
• 1370413-82-3 N-(2-(2-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 
• 1370413-83-4 N-(2-(3-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 
• 1370413-84-5 N-(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 
• 1370413-85-6 N-(2-(3,4-dihydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 
• 1370413-86-7 N-(2-(2-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 
• 1370413-87-8 N-(2-(4-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 
• 1370413-88-9 N-(2-(4-fluorophenyl)-4-oxo-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 
• 1370413-89-0 N-(2-(4-methoxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 
• 1370413-90-3 N-(2-(3,4-dimethoxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)-2,3-dihydro-1,4-benzodioxine-2-carboxamide 

Relevant articles and documents

Structure based discovery of novel hexokinase 2 inhibitors

Hexokinase 2 (HK2) is over-expressed in most of human cancers and has been proved to be a promising target for cancer therapy. In this study, based on the structure of HK2, we screened over 6 millions of compounds to obtain the lead. A total of 26 (E)-N′-(2,3,4-trihydroxybenzylidene) arylhydrazide derivatives were then designed, synthesized, and evaluated for their HK2 enzyme activity and IC50 values against two cancer cell lines. Most of the 26 target compounds showed excellently in vitro activity. Among them, compound 3j showed the strongest inhibitory effects on HK2 enzyme activity with an IC50 of 0.53 ± 0.13 μM and exhibited the most potent growth inhibition against SW480 cells with an IC50 of 7.13 ± 1.12 μM, which deserves further studies.

Containing 1,4-benzodioxane structure of the pyrazoline derivatives and the preparation and use thereof

The invention relates to pyrazoline derivatives comprising a 1,4-benzodioxan structure. The derivatives are characterized in that the derivatives have a general formula as the following. R1, R3, and R3 in the formula are as the following. The pyrazoline d

Synthesis and antibacterial activity of cinnamaldehyde acylhydrazone with a 1,4-benzodioxan fragment as a novel class of potent ss-Ketoacyl-acyl carrier protein synthase III (FabH) inhibitor

Fatty acid biosynthesis is essential for bacterial survival. ss-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH), is a particularly attractive antibacterial target, since it is central to the initiation of fatty acid biosynthesis. Three series of 2

Discovery of novel 1,4-benzodioxane containing thiazolidinone derivatives as potential antihepatotoxic agent

In continuance of our search for newer antihepatotoxic agents some novel thiazolidinone derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were evalua

Design, modification and 3D QSAR studies of novel 2,3-dihydrobenzo[b][1,4] dioxin-containing 4,5-dihydro-1H-pyrazole derivatives as inhibitors of B-Raf kinase

Two series of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives C1-C15 and D1-D15 have been synthesized and evaluated for their B-Raf inhibitory and anti-proliferation activities. Compound C14 ((3-(4-bromophenyl)-5-(2-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2,3- dihydrobenzo[b][1,4]dioxin-6-yl)methanone) showed the most potent biological activity against B-RafV600E (IC50 = 0.11 μM) and WM266.4 human melanoma cell line (GI50 = 0.58 μM), being comparable with the positive control Erlotinib and more potent than our previous best compound, while D10 ((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)(5-(3- fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone) performed the best in the D series (IC50 = 1.70 μM; GI50 = 1.45 μM). The docking simulation was performed to analyze the probable binding models and poses and the QSAR model was built for reasonable design of B-Raf inhibitors in future. The introduction of 2,3-dihydrobenzo[b][1,4]dioxin structure reinforced the combination of our compounds and the receptor, resulting in progress of bioactivity.

Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3- dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives

Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl4-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.