905590-59-2

Upstream product

• 6318-74-7 2-amino-4,5-diphenylthiazole 
• 53623-37-3 4-oxo-4-(4-ethoxyphenyl)butanoic acid 
• 905592-30-5 4-phenyl-5-(phenylmethyl)-1,3-thiazol-2-amine 

Downstream Products

• 905590-51-4 2-methyl-5-phenyl-1-[4-(trifluoromethoxy)phenyl]-1H-pyrrole-3-carboxylic acid ethyl ester 
• 905590-35-4 5-(cyclohexylmethyl)-4-phenylthiophen-2-amine 
• 52816-93-0 4-amino-2,6-diphenylpyridine 
• 905592-33-8 4-(3-ethoxyphenyl)-4-oxobutanoic acid 
• 905589-80-2 2,6-diphenylpyrimidine-4-carboxylic acid 
• 905589-83-5 [4-(methoxymethoxy)phenyl](2-nitrophenyl)methanone 
• 59086-15-6 2,5-diphenyl-3-thiophenecarboxylic acid 
• 905590-29-6 4-ethoxy-6-phenylpyridin-2-amine 
• 905590-32-1 (4-chloro-6-phenylpyridin-2-yl)amine 
• 905590-48-9 4-(4-ethoxyphenyl)-4,4-dimethoxybutanoic acid methyl ester 
• 905590-04-7 1-benzyl-5-phenyl-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

Novel acyl coenzyme A: Diacylglycerol acyltransferase 1 inhibitors - Synthesis and biological activities of N-(substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides

In a program to discover new small molecule diacylglycerol acyltransferase (DGAT)-1 inhibitors, screening of our in-house chemical library was carried out using recombinant human DGAT-1 enzyme. From this library, the lead compound 1a was identified as a n

AMIDE COMPOUND

Disclosed is a compound represented by the formula (I) or (II) below, or a salt thereof. [In the formulae, ring A represents an optionally substituted ring (which is not a pyrrolidine, piperidine or piperazine); ring B represents an optionally substituted aromatic ring; ring D represents an optionally substituted ring; R1 and R2 independently represent a hydrogen atom or a substituent; R3 represents a hydrogen atom or a C1-6 alkyl group, or alternatively it combines with the ring A to form a non-aromatic ring; ring Aa represents an optionally substituted aromatic hydrocarbon; Y represents CH or N; Ra1 represents an optionally substituted hydrocarbon group; and Ra2 and Ra3 independently represent a hydrogen atom or a substituent.] The compound has a DGAT inhibitory effect and is useful for treatment or improvement of diseases or conditions caused by high expression or high activation of DGAT.