6318-74-7

Basic information

• Product Name: Bax 439
• Synonyms: Bax 439;2-Amino-4,5-diphenylthiazole, 97%;4,5-diphenyl-1,3-thiazol-2-amine(SALTDATA: FREE);2-ThiazolaMine, 4,5-diphenyl-;4,5-Diphenyl-2-aminothiazole;4,5-Diphenylthiazol-2-amine;NSC 31689;2-Thiazolamine, 4,5-diphenyl- (9CI)
• CAS NO: 6318-74-7
• Molecular Formula: C₁₅H₁₂N₂S
• Molecular Weight: 252.34
• Mol File: 6318-74-7.mol
• Article Data: 32

Chemical Properties

• Melting Point: 189-190℃ (hexane ethyl acetate )
• Boiling Point: 420 °C at 760 mmHg
• Flash Point: 207.8 °C
• Appearance: /
• Density: 1.23 g/cm³
• Vapor Pressure: 2.9E-07mmHg at 25°C
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.02±0.10(Predicted)
• Water Solubility: Insoluble in water. Soluble in chloroform and methanol.
• CAS DataBase Reference: Bax 439(CAS DataBase Reference)
• NIST Chemistry Reference: Bax 439(6318-74-7)
• EPA Substance Registry System: Bax 439(6318-74-7)

Safety Data

• RTECS: XJ2450000
• Hazardous Substances Data: 6318-74-7(Hazardous Substances Data)

Usage

Uses

Bis(trimethylsilyl)acetylene is a ligand that binds to a central metal ion (e.g. Titanium) to create a coordination complex. One of its complexes, Permethyltitanocene-bis(trimethylsilyl)acetylene, is a catalyst for the head-to-tail dimerization of 1-alkynes (e.g. 3-Penten-1-yne).

InChI:InChI=1/C15H12N2S.ClH/c16-15-17-13(11-7-3-1-4-8-11)14(18-15)12-9-5-2-6-10-12;/h1-10H,(H2,16,17);1H

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 17356-08-0 thiourea 
• 1484-50-0 desyl bromide 
• 199915-38-3 9-fluorenylmethoxycarbonyl isothiocyanate 
• 19203-00-0 2-oxo-1,2-diphenylethyl thiocyanate 
• 333-20-0 potassium thioacyanate 
• 61954-82-3 2-amino-4-phenyl-5-bromo-1,3-thiazole 
• 98-80-6 phenylboronic acid 
• 70-11-1 α-bromoacetophenone 
• 2010-06-2 2-Amino-4-phenylthiazole 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 61795-22-0 (1-azidoethene-1,2-diyl)dibenzene 
• 1147550-11-5 ammonium thiocyanate 
• 420-04-2 CYANAMID 

Downstream Products

• 7713-93-1 bis-(4,5-diphenyl-thiazol-2-yl)-amine 
• 74636-86-5 3-(4,5-diphenyl-thiazol-2-yl)-2-phenyl-3H-quinazolin-4-one 
• 103165-68-0 2,3,5,6-tetraphenyl-imidazo[2,1-b]thiazole 
• 71638-87-4 [(4,5-diphenyl-thiazol-2-ylamino)-methylene]-malonic acid diethyl ester 
• 105197-02-2 2,4-Dibromo-6-{[(E)-4,5-diphenyl-thiazol-2-ylimino]-methyl}-phenol 
• 105212-92-8 [1-(4-Chloro-phenyl)-meth-(E)-ylidene]-(4,5-diphenyl-thiazol-2-yl)-amine 
• 105197-00-0 (4,5-Diphenyl-thiazol-2-yl)-[1-phenyl-meth-(E)-ylidene]-amine 
• 99756-64-6 4',5'-diphenylthiazole-2'-imino-(4-hydroxy)-benzylidene 
• 105196-97-2 (4,5-Diphenyl-thiazol-2-yl)-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amine 
• 105196-96-1 2-{[(E)-4,5-Diphenyl-thiazol-2-ylimino]-methyl}-phenol 
• 89405-40-3 4-{[(E)-4,5-Diphenyl-thiazol-2-ylimino]-methyl}-2-methoxy-phenol 
• 105212-91-7 [1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-(4,5-diphenyl-thiazol-2-yl)-amine 
• 105196-99-4 1-{[(E)-4,5-Diphenyl-thiazol-2-ylimino]-methyl}-naphthalen-2-ol 
• 105197-01-1 4-Bromo-2-{[(E)-4,5-diphenyl-thiazol-2-ylimino]-methyl}-phenol 

Relevant articles and documents

A one-pot synthesis of 2-aminothiazoles via the coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system

A series of 2-aminothiazoles is prepared in moderate-to-good yields by the direct coupling of ketones and thiourea using I2/dimethyl sulfoxide as a catalytic oxidative system. This method avoids the preparation of lachrymatory and toxic α-haloketones and the use of an acid-binding agent, thus providing a more convenient approach to 2-aminothiazoles compared to the Hantzsch reaction.

2-Amino-4-arylthiazoles through One-Pot Transformation of Alkylarenes with NBS and Thioureas

Treatment of alkylarenes with N-bromosuccinimide in a mixture of ethyl acetate and water at 60 °C, a mixture of acetonitrile and water at 80 °C, or a mixture of diethyl carbonate and water under irradiation with a tungsten lamp, followed by a reaction with thioureas or arenethioamides provided the corresponding 2-amino- 4-arylthiazoles or 2,4-diarylthiazoles in good to moderate yields, respectively, in one pot. The present reaction is an efficient one-pot transformation method of alkylarenes into 2-amino-4-arylthiazoles and 2,4-diarylthiazoles directly under mild and transition-metal-free conditions.

SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.