905601-20-9Relevant academic research and scientific papers
Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme
Gobbi, Silvia,Cavalli, Andrea,Rampa, Angela,Belluti, Federica,Piazzi, Lorna,Paluszcak, Anja,Hartmann, Rolf W.,Recanatini, Maurizio,Bisi, Alessandra
, p. 4777 - 4780 (2006)
Following our SAR studies on aromatase inhibitors, new compounds were designed by appropriately modifying the structure of flavone 1 using our previously reported CoMFA model. While the introduction of substituents on the 2-phenyl ring alone did not cause
