905752-06-9Relevant academic research and scientific papers
A synthesis of sulfonamide analogs of platensimycin employing a palladium-mediated carbonylation strategy
McNulty, James,Nair, Jerald J.,Capretta, Alfredo
scheme or table, p. 4087 - 4091 (2009/12/01)
The monodentate ligand 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phospha-adamantane (PA-Ph) is shown to be highly effective in palladium-catalyzed carbonylative cross-coupling. Aryl and vinyl halides were efficiently converted to carboxylic acids, amides and to primary, secondary, and tertiary esters, respectively. Application of the Pd(OAc)2/PA-Ph (1:1) catalyst system proved critical in the methoxycarbonylation of a functionalized nitroresorcinol halide, allowing convenient access to novel platensimycin sulfonamide analogs.
NOVEL TUBULIN POLYMERISATION INHIBITORS
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Page/Page column 86, (2008/06/13)
The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds.
