90585-28-7

Usage

Derivative of acetic acid

It is a modified version of acetic acid The compound is derived from acetic acid by attaching an iodinated phenyl ring to the acetic acid structure.

Iodine atom

Contains an iodine atom The presence of the iodine atom in the compound contributes to its chemical reactivity and potential applications in various fields.

Methyl group

Has a methyl group attached to a phenyl ring The methyl group adds steric hindrance and electronic effects to the compound, affecting its properties and reactivity.

Organic synthesis reagent

Commonly used as a reagent in organic synthesis The compound serves as a building block or intermediate in the synthesis of more complex organic molecules.

Pharmaceutical research

Utilized in pharmaceutical research 2-(2-iodo-4-methylphenyl)acetic acid is studied for its potential use in the development of new medications.

Anti-inflammatory properties

Exhibits anti-inflammatory properties The compound has the ability to reduce inflammation, which may be useful in the treatment of various inflammatory conditions.

Analgesic properties

Has analgesic properties The compound can help relieve pain, making it a potential candidate for pain management applications.

Analytical chemistry reference standard

Used as a reference standard in analytical chemistry The compound serves as a benchmark for comparing and validating analytical methods and techniques.

Versatile compound

Versatile compound with a wide range of potential applications 2-(2-iodo-4-methylphenyl)acetic acid has various applications in science and industry, including organic synthesis, pharmaceutical research, and analytical chemistry.

Upstream product

• 622-47-9 4-tolylacetic acid 
• 126156-28-3 2-iodo-4-methylbenzaldehyde 
• 29289-13-2 2-iodo-4-methylaniline 
• 1241405-25-3 C₉H₉IO 

Downstream Products

• 90585-27-6 methyl 2-iodo-4-methylphenylacetate 
• 1241405-38-8 methyl 1-[3-iodo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate 
• 1313592-03-8 sodium 2-{2-iodo-4-[(2-oxocyclopentyl)methyl]phenyl}propanoate 
• 1241405-34-4 C₁₁H₁₂BrIO₂ 
• 1241405-30-0 methyl 2-(2-iodo-4-methylphenyl)propanoate 
• 344443-58-9 methyl 4-methyl-2-(1-pentyl)phenylacetate 
• 90585-06-1 methyl β-<4-methyl-2-(1-pentyl)phenyl>ethyl ether 
• 90585-29-8 methyl β-(2-iodo-4-methylphenyl)ethyl ether 
• 90585-30-1 β-(2-iodo-4-methylphenyl)ethyl alcohol 

Relevant academic research and scientific papers

Synthesis of N-Glycosyl-2-oxindoles by Pd-Catalyzed N-Arylation of 1-Amidosugars

An efficient intramolecular Pd-catalyzed N-arylation of o-iodo-amidosugars for the synthesis of N-glycosylated oxindoles has been reported. The coupling reaction takes place in toluene and involves Pd(OAc)2/RuPhos catalytic systems in the presence of K2CO3. This versatile approach was extended successfully to the synthesis of other N-glycosylated heterocycles.

Enantioselective Allylic C?H Oxidation of Terminal Olefins to Isochromans by Palladium(II)/Chiral Sulfoxide Catalysis

The enantioselective synthesis of isochroman motifs has been accomplished by palladium(II)-catalyzed allylic C?H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sul

Efficient synthesis of heterocyle-fused β-naphthylamines via intramolecular addition to a cyano group initiated by nucleopalladation of alkynes

A palladium(II)-catalyzed efficient synthesis of heterocycle-fused-naphthylamines was accomplished via nucleophilic addition of a carbon-palladium bond to the intramolecular cyano group initiated by nucleopalladation (oxypalladation or aminopalladation) o

LOXOPROFEN DERIVATIVE AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME

There is provided a novel loxoprofen derivative that has no side effect such as a gastrointestinal disorder and also has excellent anti-inflammatory and analgesic effects and is represented by the following formula (I) or (II): (wherein R1 and

Synthesis and biological evaluation of loxoprofen derivatives

Non-steroidal anti-inflammatory drugs (NSAIDs) achieve their anti-inflammatory actions through an inhibitory effect on cyclooxygenase (COX). Two COX subtypes, COX-1 and COX-2, are responsible for the majority of COX activity at the gastrointestinal mucosa and in tissues with inflammation, respectively. We previously suggested that both gastric mucosal cell death due to the membrane permeabilization activity of NSAIDs and COX-inhibition at the gastric mucosa are involved in NSAID-induced gastric lesions. We have also reported that loxoprofen has the lowest membrane permeabilization activity among the NSAIDs we tested. In this study, we synthesized a series of loxoprofen derivatives and examined their membrane permeabilization activities and inhibitory effects on COX-1 and COX-2. Among these derivatives, 2-{4′-hydroxy-5-[(2-oxocyclopentyl)methyl]biphenyl-2-yl}propanoate 31 has a specificity for COX-2 over COX-1. Compared to loxoprofen, oral administration of 31 to rats produced fewer gastric lesions but showed an equivalent anti-inflammatory effect. These results suggest that 31 is likely to be a therapeutically beneficial and safer NSAID.

Expedient drug synthesis and diversification via ortho-C-H iodination using recyclable PdI2 as the precatalyst

(Figure Presented) Pd(II)-catalyzed ortho-C-H iodination reactions of phenylacetic acid substrates have been achieved using recyclable PdI2 as the precatalyst. This class of substrates is incompatible with the classic amide formation/ortho-lithiation/iodination sequence. The power of this new technology is demonstrated by facile drug functionalization and drastically shortened syntheses of the drugs diclofenac and lumiracoxib.

Mercury in Organic Chemistry. 26. Synthesis of Heterocycles via Intramolecular Solvomercuration of Aryl Acetylenes

A number of ortho substituted aryl acetylenes, o-CH3XC6H4YCCR (X=O, S, CO2; Y=-, CO), have been observed to undergo facile intramolecular solvomercuration with mercuric acetate in acetic acid to afford the corresponding benzofuran, benzothiophene, isocoumarin, and chromone organomercuric chlorides, after aqueous sodium chloride workup.The aryl acetylenes m-XC6H4YCH2CCR (X=H, Y=O, R=CH3; X=CH3O, Y=CH2, R=n-C3H7) undergo similar cyclizations to yield mercurated 2H-1-benzopyrans and 1,2-dihydronaphthalenes.The mercuration and subsequent carbonylation of o-R1OC6H4CCR2 1=Si(t-Bu)Me2, R2=CH3; R1=CH3, R2=o-C6H4OCH3> has provided a new approach to the coumarin and coumestan ring systems.