905916-01-0

Basic information

• Product Name: (1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile
• Synonyms: (1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile
• CAS NO: 905916-01-0
• Molecular Weight: 306.407
• Mol File: 905916-01-0.mol

Chemical Properties

• CAS DataBase Reference: (1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile(905916-01-0)
• EPA Substance Registry System: (1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile(905916-01-0)

Safety Data

• Hazardous Substances Data: 905916-01-0(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 143-33-9 sodium cyanide 
• 206751-75-9 α-benzyloxycyclobutanone 
• 737758-92-8 (S)-(-)-2-benzyloxycyclobutanone 

Downstream Products

• 905916-02-1 (1R,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarbonitrile 
• 905916-06-5 (1S,2S,1'S)-2-benzyloxy-1-[(1'-phenylethyl)amino]cyclobutanecarboxamide 

Relevant articles and documents

Stereoselective synthesis of (1R,2R)-1-amino-2-hydroxycyclobutanecarboxylic acid-serine derivative-, from racemic or optically active 2-benzyloxycyclobutanone

An easy and efficient one-pot reaction from readily available 2-benzyloxycyclobutanone gave, by means of an asymmetric Strecker synthesis, a kinetic or thermodynamic nitrile with good selectivity. After separation, the major trans-amino nitrile underwent basic hydrolysis and hydrogenolysis, followed by acidic hydrolysis, to give optically active (1R,2R)-1-amino-2-hydroxycyclobutanecarboxylic acid, serine derivative. The absolute configuration has been established by X-ray analysis of the corresponding cis-amino nitrile.