206751-75-9

Basic information

• Product Name: α-benzyloxycyclobutanone
• Synonyms: α-benzyloxycyclobutanone
• CAS NO: 206751-75-9
• Molecular Weight: 176.215
• Mol File: 206751-75-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: α-benzyloxycyclobutanone(CAS DataBase Reference)
• NIST Chemistry Reference: α-benzyloxycyclobutanone(206751-75-9)
• EPA Substance Registry System: α-benzyloxycyclobutanone(206751-75-9)

Safety Data

• Hazardous Substances Data: 206751-75-9(Hazardous Substances Data)

Usage

General Description

α-benzyloxycyclobutanone is a chemical compound with the molecular formula C11H12O2. It is a cyclic ketone derivative, containing a cyclobutanone ring with a benzyl group attached to it. α-benzyloxycyclobutanone is commonly used in organic synthesis as a building block or intermediate for various reactions, due to its reactivity and ability to undergo a range of transformations. It is also a useful substrate in the study of organic chemistry and is often employed in the development of new synthetic methods. α-benzyloxycyclobutanone has potential applications in the pharmaceutical and agrochemical industries as well, as it can be used in the production of various fine chemicals and active pharmaceutical ingredients.

Upstream product

• 17082-61-0 1,2-bis(trimethylsiloxy)cyclobutene 
• 100-51-6 benzyl alcohol 
• 99440-99-0 2-hydroxycyclobutanone 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma

A new [18F] labeled amino acid anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid 9 (anti-2-[18F]FACBC) was synthesized in 30% decay-corrected yield with high radiochemical purity over 99%. The cyclic sulfamidate precursor was very stable and highly reactive towards nucleophilic radiofluorination. Cell uptake assays with rat 9L gliosarcoma cells showed that [18F]9 was transported into tumor cells via multiple amino acid transport systems, including L and A systems. Biodistribution study in rats with intracranial 9L gliosarcoma tumors demonstrated that [18F]9 had a rapid and prolonged accumulation in tumors with 26:1 tumor to brain ratio at 120 min post-injection. In this model, [18F]9 is a potential PET tracer for brain tumor imaging.

SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE

Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Acid-catalyzed reaction of 2-hydroxycyclobutanone with benzylic alcohols

The acid-promoted syntheses of 2-(benzyloxy)cyclobutanones and bis(benzyloxy)dioxatricyclo decanes were achieved starting from 2-hydroxycyclobutanone and variously functionalized benzyl alcohols. The reaction sequences afforded the desired products in good to high yields and in a solvent-dependent chemoselective fashion.