905967-72-8 Usage
Molecular structure
A complex chemical compound containing a pyrrole ring, an acetamide group, and a phenyl ring with a trifluoromethyl substituent.
Aminoiminomethyl substituent
A functional group attached to the phenyl ring, contributing to the compound's reactivity and potential applications.
Fluorine content
The presence of a trifluoromethyl group indicates a high electronegativity and potential for hydrogen bonding, which can influence the compound's properties and interactions.
Diverse functional groups
The presence of a pyrrole ring, acetamide group, and phenyl ring with a trifluoromethyl substituent suggests a wide range of possible applications and interactions with biological targets.
Potential applications
Given its unique structure and functional groups, 1H-Pyrrole-1-acetamide,
N-(aminoiminomethyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]- may have various applications in pharmaceuticals, agrochemicals, or materials science.
Need for further research
To fully understand the properties and potential uses of 1H-Pyrrole-1-acetamide,
N-(aminoiminomethyl)-2-phenyl-5-[4-(trifluoromethyl)phenyl]-, additional research and experimentation are required.
Check Digit Verification of cas no
The CAS Registry Mumber 905967-72-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,5,9,6 and 7 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 905967-72:
(8*9)+(7*0)+(6*5)+(5*9)+(4*6)+(3*7)+(2*7)+(1*2)=208
208 % 10 = 8
So 905967-72-8 is a valid CAS Registry Number.
905967-72-8Relevant academic research and scientific papers
Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets
Cole, Derek C.,Stock, Joseph R.,Chopra, Rajiv,Cowling, Rebecca,Ellingboe, John W.,Fan, Kristi Y.,Harrison, Boyd L.,Hu, Yun,Jacobsen, Steve,Jennings, Lee D.,Jin, Guixian,Lohse, Peter A.,Malamas, Michael S.,Manas, Eric S.,Moore, William J.,O'Donnell, Mary-Margaret,Olland, Andrea M.,Robichaud, Albert J.,Svenson, Kristine,Wu, JunJun,Wagner, Eric,Bard, Jonathan
, p. 1063 - 1066 (2008/09/19)
Proteolytic cleavage of amyloid precursor protein by β-secretase (BACE-1) and γ-secretase leads to formation of β-amyloid (Aβ) a key component of amyloid plaques, which are considered the hallmark of Alzheimer's disease. Small molecule inhibitors of BACE-1 may reduce levels of Aβ and thus have therapeutic potential for treating Alzheimer's disease. We recently reported the identification of a novel small molecule BACE-1 inhibitor N-[2-(2,5-diphenyl-pyrrol-1-yl)-acetyl]guanidine (3.a.1). We report here the initial hit-to-lead optimization of this hit and the SAR around the aryl groups occupying the S1 and S2′ pockets leading to submicromolar BACE-1 inhibitors.
