905970-29-8Relevant academic research and scientific papers
Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1′ substrate binding pocket
Jennings, Lee D.,Cole, Derek C.,Stock, Joseph R.,Sukhdeo, Mohani N.,Ellingboe, John W.,Cowling, Rebecca,Jin, Guixian,Manas, Eric S.,Fan, Kristi Y.,Malamas, Michael S.,Harrison, Boyd L.,Jacobsen, Steve,Chopra, Rajiv,Lohse, Peter A.,Moore, William J.,O'Donnell, Mary-Margaret,Hu, Yun,Robichaud, Albert J.,Turner, M. James,Wagner, Erik,Bard, Jonathan
, p. 767 - 771 (2008)
The proteolytic enzyme β-secretase (BACE-1) produces amyloid β (Aβ) peptide, the primary constituent of neurofibrillary plaques, implicated in Alzheimer's disease, by cleavage of the amyloid precursor protein. A small molecule inhibitor of BACE-1, (diamin
