Bioorganic and Medicinal Chemistry Letters p. 767 - 771 (2008)
Update date:2022-08-03
Topics:
Jennings, Lee D.
Cole, Derek C.
Stock, Joseph R.
Sukhdeo, Mohani N.
Ellingboe, John W.
Cowling, Rebecca
Jin, Guixian
Manas, Eric S.
Fan, Kristi Y.
Malamas, Michael S.
Harrison, Boyd L.
Jacobsen, Steve
Chopra, Rajiv
Lohse, Peter A.
Moore, William J.
O'Donnell, Mary-Margaret
Hu, Yun
Robichaud, Albert J.
Turner, M. James
Wagner, Erik
Bard, Jonathan
The proteolytic enzyme β-secretase (BACE-1) produces amyloid β (Aβ) peptide, the primary constituent of neurofibrillary plaques, implicated in Alzheimer's disease, by cleavage of the amyloid precursor protein. A small molecule inhibitor of BACE-1, (diamin
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