906070-38-0

Upstream product

• 406680-79-3 Boc-L-Tyr-L-Val-OMe 
• 3978-80-1 Boc-Tyr-OH 
• 6306-52-1 L-valine methylester hydrochloride 
• 88224-01-5 L-valine allyl ester 

Downstream Products

• 454423-93-9 [(S)-1-{(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 454423-95-1 [(S)-1-{(S)-1-[2-(2-Bromo-ethoxy)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BACKGROUND

Disclosed herein are small molecule calpain modulators, pharmaceutical compositions, preparation methods and their use as therapeutic agents. The therapeutic agents can be used for treating fibrotic disease or a resulting secondary disease state or condition. The small molecules can inhibit calpain through contact with CAPN1, CAPN2, and/or CAPN9 enzymes.

Design and synthesis of broad-based mono- and bi- cyclic inhibitors of FIV and HIV proteases

Based on the substrate transition state and our strategy to tackle the problem of drug resistance, a series of HIV/FIV protease (HIV/FIV PR) monocyclic inhibitors incorporating a 15- or 17-membered macrocycle with an equivalent P3 or P3′ group and a uniqu