906095-17-8Relevant academic research and scientific papers
BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
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Page/Page column 67, (2009/08/16)
A compound having the structure set forth in Formula (I) or Formula (II): wherein the variables Y, R1, R2, R3, and R4 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
Benzoxazole carboxamides for treating CINV and IBS-D
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Page/Page column 15-16, (2008/06/13)
Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to treat IBS-D.
Microwave-assisted synthesis of benzoxazole-7-carboxylate esters using trifluoroacetic acid and acetic acid
Huxley, Anthony
, p. 2658 - 2660 (2008/09/16)
Existing routes to benzoxazole-7-carboxylates are low-yielding. The following letter describes a new methodology for the synthesis of benzoxazole-7-carboxylates in much improved yield using trifluoroacetic acid-acetic acid and microwave irradiation. Georg
