906097-72-1Relevant academic research and scientific papers
Total synthesis of clavepictines A and B and pictamine
Yu, Shanghai,Pu, Xiaotao,Cheng, Tiejun,Wang, Renxiao,Ma, Dawei
, p. 3179 - 3182 (2006)
A short route for assembling clavepictines A and B and pictamine is described, which features elaboration of its trisubstituted piperidine moiety via condensation of a β-keto sulfone with an L-alanine-derived bromide and subsequent alkylative cyclization and construction of its quinolizidine skeleton via a diastereoselective intramolecular conjugate addition. The possible stereochemical course for this conjugate addition is discussed.
